Stevens-Johnson Syndrome Caused by Enzalutamide: A Case Report and Literature Review

OBJECTIVE: Enzalutamide is the most frequently prescribed compound for treating metastatic castration-resistant prostate cancer (mCRPC). Common adverse drug events of enzalutamide are febrile neutropenia, hot flashes, hypertension, and fatigue. METHODS: We present a case of a patient with mCRPC who received enzalutamide and developed Stevens-Johnson syndrome (SJS). The culprit drug was confirmed using the Naranjo Adverse Drug Reaction Probability Scale. Clinical characteristics and management principles were analyzed in combination with literature reports. RESULTS: SJS occurred within two weeks of enzalutamide therapy. Supportive care such as steroid treatment led to a complete resolution of skin lesions and improved clinical symptoms after three weeks. CONCLUSION: Most cutaneous adverse events occur early during enzalutamide therapy, and close observation should be given within two weeks of starting treatment.