Genotype I African swine fever viruses emerged in domestic pigs in China and caused chronic infection

The Georgia-07-like genotype II African swine fever virus (ASFV) with high virulence has been prevalent in China since 2018. Here, we report that genotype I ASFVs have now also emerged in China. Two non-haemadsorbing genotype I ASFVs, HeN/ZZ-P1/21 and SD/DY-I/21, were isolated from pig farms in Hena...

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Detalles Bibliográficos
Autores principales: Sun, Encheng, Huang, Lianyu, Zhang, Xianfeng, Zhang, Jiwen, Shen, Dongdong, Zhang, Zhenjiang, Wang, Zilong, Huo, Hong, Wang, Wenqing, Huangfu, Haoyue, Wang, Wan, Li, Fang, Liu, Renqiang, Sun, Jianhong, Tian, Zhijun, Xia, Wei, Guan, Yuntao, He, Xijun, Zhu, Yuanmao, Zhao, Dongming, Bu, Zhigao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635679/
https://www.ncbi.nlm.nih.gov/pubmed/34709128
http://dx.doi.org/10.1080/22221751.2021.1999779
Descripción
Sumario:The Georgia-07-like genotype II African swine fever virus (ASFV) with high virulence has been prevalent in China since 2018. Here, we report that genotype I ASFVs have now also emerged in China. Two non-haemadsorbing genotype I ASFVs, HeN/ZZ-P1/21 and SD/DY-I/21, were isolated from pig farms in Henan and Shandong province, respectively. Phylogenetic analysis of the whole genome sequences suggested that both isolates share high similarity with NH/P68 and OURT88/3, two genotype I ASFVs isolated in Portugal in the last century. Animal challenge testing revealed that SD/DY-I/21 shows low virulence and efficient transmissibility in pigs, and causes mild onset of infection and chronic disease. SD/DY-I/21 was found to cause necrotic skin lesions and joint swelling. The emergence of genotype I ASFVs will present more problems and challenges for the control and prevention of African swine fever in China.

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