Highlighting the Place of Metastasis-Directed Therapy in Isolated Liver Metastases in Prostate Cancer: A Case Report

Metastatic prostate cancer remains a challenge for clinicians. Metastases involve mainly the bone compartment and can manifest as oligometastatic disease. In this setting, the role of metastasis-directed therapies (MDT) including surgery and/or stereotactic body radiotherapy is currently evaluated....

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Autores principales: Yeo, Anne-Emmanuella, Hendrix, Aurore, Confente, Caterina, Christian, Nicolas, Mansvelt, Baudouin, Pairet, Géraldine, Seront, Emmanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635688/
https://www.ncbi.nlm.nih.gov/pubmed/34868986
http://dx.doi.org/10.3389/fonc.2021.764758
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author Yeo, Anne-Emmanuella
Hendrix, Aurore
Confente, Caterina
Christian, Nicolas
Mansvelt, Baudouin
Pairet, Géraldine
Seront, Emmanuel
author_facet Yeo, Anne-Emmanuella
Hendrix, Aurore
Confente, Caterina
Christian, Nicolas
Mansvelt, Baudouin
Pairet, Géraldine
Seront, Emmanuel
author_sort Yeo, Anne-Emmanuella
collection PubMed
description Metastatic prostate cancer remains a challenge for clinicians. Metastases involve mainly the bone compartment and can manifest as oligometastatic disease. In this setting, the role of metastasis-directed therapies (MDT) including surgery and/or stereotactic body radiotherapy is currently evaluated. Visceral metastases are less common and have very poor prognosis in mPC. Whether treating isolated visceral metastases such as liver metastases with MDT could increase the prognosis remains unknown. We report the management of a prostate cancer patient who progressed on androgen deprivation therapy with apparition of two liver metastases. We describe the feasibility of combining MDT with abiraterone acetate and prednisone in a patient with metastatic castration-resistant prostate cancer. MDT allowed the interruption of abiraterone acetate, preventing cumulative toxicity of this agent.
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spelling pubmed-86356882021-12-02 Highlighting the Place of Metastasis-Directed Therapy in Isolated Liver Metastases in Prostate Cancer: A Case Report Yeo, Anne-Emmanuella Hendrix, Aurore Confente, Caterina Christian, Nicolas Mansvelt, Baudouin Pairet, Géraldine Seront, Emmanuel Front Oncol Oncology Metastatic prostate cancer remains a challenge for clinicians. Metastases involve mainly the bone compartment and can manifest as oligometastatic disease. In this setting, the role of metastasis-directed therapies (MDT) including surgery and/or stereotactic body radiotherapy is currently evaluated. Visceral metastases are less common and have very poor prognosis in mPC. Whether treating isolated visceral metastases such as liver metastases with MDT could increase the prognosis remains unknown. We report the management of a prostate cancer patient who progressed on androgen deprivation therapy with apparition of two liver metastases. We describe the feasibility of combining MDT with abiraterone acetate and prednisone in a patient with metastatic castration-resistant prostate cancer. MDT allowed the interruption of abiraterone acetate, preventing cumulative toxicity of this agent. Frontiers Media S.A. 2021-11-17 /pmc/articles/PMC8635688/ /pubmed/34868986 http://dx.doi.org/10.3389/fonc.2021.764758 Text en Copyright © 2021 Yeo, Hendrix, Confente, Christian, Mansvelt, Pairet and Seront https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Yeo, Anne-Emmanuella
Hendrix, Aurore
Confente, Caterina
Christian, Nicolas
Mansvelt, Baudouin
Pairet, Géraldine
Seront, Emmanuel
Highlighting the Place of Metastasis-Directed Therapy in Isolated Liver Metastases in Prostate Cancer: A Case Report
title Highlighting the Place of Metastasis-Directed Therapy in Isolated Liver Metastases in Prostate Cancer: A Case Report
title_full Highlighting the Place of Metastasis-Directed Therapy in Isolated Liver Metastases in Prostate Cancer: A Case Report
title_fullStr Highlighting the Place of Metastasis-Directed Therapy in Isolated Liver Metastases in Prostate Cancer: A Case Report
title_full_unstemmed Highlighting the Place of Metastasis-Directed Therapy in Isolated Liver Metastases in Prostate Cancer: A Case Report
title_short Highlighting the Place of Metastasis-Directed Therapy in Isolated Liver Metastases in Prostate Cancer: A Case Report
title_sort highlighting the place of metastasis-directed therapy in isolated liver metastases in prostate cancer: a case report
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635688/
https://www.ncbi.nlm.nih.gov/pubmed/34868986
http://dx.doi.org/10.3389/fonc.2021.764758
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