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Mean Scar Entropy by Late Gadolinium Enhancement Cardiac Magnetic Resonance Is Associated With Ventricular Arrhythmias Events in Hypertrophic Cardiomyopathy
Background: Ventricular arrhythmias are associated with sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM). Previous studies have found the late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) was independently associated with ventricular arrhythmia (VA) in HCM. The ris...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635716/ https://www.ncbi.nlm.nih.gov/pubmed/34869672 http://dx.doi.org/10.3389/fcvm.2021.758635 |
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author | Ye, Yang Ji, ZhongPing Zhou, Wenli Pu, Cailing Li, Ya Zhou, Chengqin Hu, Xiuhua Chen, Chao Sun, Yaxun Huang, Qi Zhang, Wenjuan Qian, Yu'e Ren, Hong Yu, Feidan Jiang, Chenyang Mao, Yankai Wang, Bei Augusto, João B. Lai, Dongwu Hu, Hongjie Fu, Guo-sheng |
author_facet | Ye, Yang Ji, ZhongPing Zhou, Wenli Pu, Cailing Li, Ya Zhou, Chengqin Hu, Xiuhua Chen, Chao Sun, Yaxun Huang, Qi Zhang, Wenjuan Qian, Yu'e Ren, Hong Yu, Feidan Jiang, Chenyang Mao, Yankai Wang, Bei Augusto, João B. Lai, Dongwu Hu, Hongjie Fu, Guo-sheng |
author_sort | Ye, Yang |
collection | PubMed |
description | Background: Ventricular arrhythmias are associated with sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM). Previous studies have found the late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) was independently associated with ventricular arrhythmia (VA) in HCM. The risk stratification of VA remains complex and LGE is present in the majority of HCM patients. This study was conducted to determine whether the scar heterogeneity from LGE-derived entropy is associated with the VAs in HCM patients. Materials and Methods: Sixty-eight HCM patients with scarring were retrospectively enrolled and divided into VA (31 patients) and non-VA (37 patients) groups. The left ventricular ejection fraction (LVEF) and percentage of the LGE (% LGE) were evaluated. The scar heterogeneity was quantified by the entropy within the scar and left ventricular (LV) myocardium. Results: Multivariate analyses showed that a higher scar [hazard ratio (HR) 2.682; 95% CI: 1.022–7.037; p = 0.039] was independently associated with VA, after the adjustment for the LVEF, %LGE, LV maximal wall thickness (MWT), and left atrium (LA) diameter. Conclusion: Scar entropy and %LGE are both independent risk indicators of VA. A high scar entropy may indicate an arrhythmogenic scar, an identification of which may have value for the clinical status assessment of VAs in HCM patients. |
format | Online Article Text |
id | pubmed-8635716 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86357162021-12-02 Mean Scar Entropy by Late Gadolinium Enhancement Cardiac Magnetic Resonance Is Associated With Ventricular Arrhythmias Events in Hypertrophic Cardiomyopathy Ye, Yang Ji, ZhongPing Zhou, Wenli Pu, Cailing Li, Ya Zhou, Chengqin Hu, Xiuhua Chen, Chao Sun, Yaxun Huang, Qi Zhang, Wenjuan Qian, Yu'e Ren, Hong Yu, Feidan Jiang, Chenyang Mao, Yankai Wang, Bei Augusto, João B. Lai, Dongwu Hu, Hongjie Fu, Guo-sheng Front Cardiovasc Med Cardiovascular Medicine Background: Ventricular arrhythmias are associated with sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM). Previous studies have found the late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) was independently associated with ventricular arrhythmia (VA) in HCM. The risk stratification of VA remains complex and LGE is present in the majority of HCM patients. This study was conducted to determine whether the scar heterogeneity from LGE-derived entropy is associated with the VAs in HCM patients. Materials and Methods: Sixty-eight HCM patients with scarring were retrospectively enrolled and divided into VA (31 patients) and non-VA (37 patients) groups. The left ventricular ejection fraction (LVEF) and percentage of the LGE (% LGE) were evaluated. The scar heterogeneity was quantified by the entropy within the scar and left ventricular (LV) myocardium. Results: Multivariate analyses showed that a higher scar [hazard ratio (HR) 2.682; 95% CI: 1.022–7.037; p = 0.039] was independently associated with VA, after the adjustment for the LVEF, %LGE, LV maximal wall thickness (MWT), and left atrium (LA) diameter. Conclusion: Scar entropy and %LGE are both independent risk indicators of VA. A high scar entropy may indicate an arrhythmogenic scar, an identification of which may have value for the clinical status assessment of VAs in HCM patients. Frontiers Media S.A. 2021-11-17 /pmc/articles/PMC8635716/ /pubmed/34869672 http://dx.doi.org/10.3389/fcvm.2021.758635 Text en Copyright © 2021 Ye, Ji, Zhou, Pu, Li, Zhou, Hu, Chen, Sun, Huang, Zhang, Qian, Ren, Yu, Jiang, Mao, Wang, Augusto, Lai, Hu and Fu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cardiovascular Medicine Ye, Yang Ji, ZhongPing Zhou, Wenli Pu, Cailing Li, Ya Zhou, Chengqin Hu, Xiuhua Chen, Chao Sun, Yaxun Huang, Qi Zhang, Wenjuan Qian, Yu'e Ren, Hong Yu, Feidan Jiang, Chenyang Mao, Yankai Wang, Bei Augusto, João B. Lai, Dongwu Hu, Hongjie Fu, Guo-sheng Mean Scar Entropy by Late Gadolinium Enhancement Cardiac Magnetic Resonance Is Associated With Ventricular Arrhythmias Events in Hypertrophic Cardiomyopathy |
title | Mean Scar Entropy by Late Gadolinium Enhancement Cardiac Magnetic Resonance Is Associated With Ventricular Arrhythmias Events in Hypertrophic Cardiomyopathy |
title_full | Mean Scar Entropy by Late Gadolinium Enhancement Cardiac Magnetic Resonance Is Associated With Ventricular Arrhythmias Events in Hypertrophic Cardiomyopathy |
title_fullStr | Mean Scar Entropy by Late Gadolinium Enhancement Cardiac Magnetic Resonance Is Associated With Ventricular Arrhythmias Events in Hypertrophic Cardiomyopathy |
title_full_unstemmed | Mean Scar Entropy by Late Gadolinium Enhancement Cardiac Magnetic Resonance Is Associated With Ventricular Arrhythmias Events in Hypertrophic Cardiomyopathy |
title_short | Mean Scar Entropy by Late Gadolinium Enhancement Cardiac Magnetic Resonance Is Associated With Ventricular Arrhythmias Events in Hypertrophic Cardiomyopathy |
title_sort | mean scar entropy by late gadolinium enhancement cardiac magnetic resonance is associated with ventricular arrhythmias events in hypertrophic cardiomyopathy |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635716/ https://www.ncbi.nlm.nih.gov/pubmed/34869672 http://dx.doi.org/10.3389/fcvm.2021.758635 |
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