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Oral Osteomicrobiology: The Role of Oral Microbiota in Alveolar Bone Homeostasis

Osteomicrobiology is a new research field in which the aim is to explore the role of microbiota in bone homeostasis. The alveolar bone is that part of the maxilla and mandible that supports the teeth. It is now evident that naturally occurring alveolar bone loss is considerably stunted in germ-free...

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Autores principales: Cheng, Xingqun, Zhou, Xuedong, Liu, Chengcheng, Xu, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635720/
https://www.ncbi.nlm.nih.gov/pubmed/34869060
http://dx.doi.org/10.3389/fcimb.2021.751503
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author Cheng, Xingqun
Zhou, Xuedong
Liu, Chengcheng
Xu, Xin
author_facet Cheng, Xingqun
Zhou, Xuedong
Liu, Chengcheng
Xu, Xin
author_sort Cheng, Xingqun
collection PubMed
description Osteomicrobiology is a new research field in which the aim is to explore the role of microbiota in bone homeostasis. The alveolar bone is that part of the maxilla and mandible that supports the teeth. It is now evident that naturally occurring alveolar bone loss is considerably stunted in germ-free mice compared with specific-pathogen-free mice. Recently, the roles of oral microbiota in modulating host defense systems and alveolar bone homeostasis have attracted increasing attention. Moreover, the mechanistic understanding of oral microbiota in mediating alveolar bone remodeling processes is undergoing rapid progress due to the advancement in technology. In this review, to provide insight into the role of oral microbiota in alveolar bone homeostasis, we introduced the term “oral osteomicrobiology.” We discussed regulation of alveolar bone development and bone loss by oral microbiota under physiological and pathological conditions. We also focused on the signaling pathways involved in oral osteomicrobiology and discussed the bridging role of osteoimmunity and influencing factors in this process. Finally, the critical techniques for osteomicrobiological investigations were introduced.
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spelling pubmed-86357202021-12-02 Oral Osteomicrobiology: The Role of Oral Microbiota in Alveolar Bone Homeostasis Cheng, Xingqun Zhou, Xuedong Liu, Chengcheng Xu, Xin Front Cell Infect Microbiol Cellular and Infection Microbiology Osteomicrobiology is a new research field in which the aim is to explore the role of microbiota in bone homeostasis. The alveolar bone is that part of the maxilla and mandible that supports the teeth. It is now evident that naturally occurring alveolar bone loss is considerably stunted in germ-free mice compared with specific-pathogen-free mice. Recently, the roles of oral microbiota in modulating host defense systems and alveolar bone homeostasis have attracted increasing attention. Moreover, the mechanistic understanding of oral microbiota in mediating alveolar bone remodeling processes is undergoing rapid progress due to the advancement in technology. In this review, to provide insight into the role of oral microbiota in alveolar bone homeostasis, we introduced the term “oral osteomicrobiology.” We discussed regulation of alveolar bone development and bone loss by oral microbiota under physiological and pathological conditions. We also focused on the signaling pathways involved in oral osteomicrobiology and discussed the bridging role of osteoimmunity and influencing factors in this process. Finally, the critical techniques for osteomicrobiological investigations were introduced. Frontiers Media S.A. 2021-11-17 /pmc/articles/PMC8635720/ /pubmed/34869060 http://dx.doi.org/10.3389/fcimb.2021.751503 Text en Copyright © 2021 Cheng, Zhou, Liu and Xu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Cheng, Xingqun
Zhou, Xuedong
Liu, Chengcheng
Xu, Xin
Oral Osteomicrobiology: The Role of Oral Microbiota in Alveolar Bone Homeostasis
title Oral Osteomicrobiology: The Role of Oral Microbiota in Alveolar Bone Homeostasis
title_full Oral Osteomicrobiology: The Role of Oral Microbiota in Alveolar Bone Homeostasis
title_fullStr Oral Osteomicrobiology: The Role of Oral Microbiota in Alveolar Bone Homeostasis
title_full_unstemmed Oral Osteomicrobiology: The Role of Oral Microbiota in Alveolar Bone Homeostasis
title_short Oral Osteomicrobiology: The Role of Oral Microbiota in Alveolar Bone Homeostasis
title_sort oral osteomicrobiology: the role of oral microbiota in alveolar bone homeostasis
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635720/
https://www.ncbi.nlm.nih.gov/pubmed/34869060
http://dx.doi.org/10.3389/fcimb.2021.751503
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