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Lateralized Contributions of Medial Prefrontal Cortex Network to Episodic Memory Deficits in Subjects With Amnestic Mild Cognitive Impairment

Both episodic memory and executive function are impaired in amnestic mild cognitive impairment (aMCI) subjects, but it is unclear if these impairments are independent or interactive. The present study aimed to explore the relationship between episodic memory deficits and executive function deficits,...

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Autores principales: Ye, Qing, Chen, Haifeng, Liu, Renyuan, Qin, Ruomeng, Luo, Caimei, Li, Mengchun, Xu, Yun, Zhao, Hui, Bai, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635729/
https://www.ncbi.nlm.nih.gov/pubmed/34867283
http://dx.doi.org/10.3389/fnagi.2021.756241
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author Ye, Qing
Chen, Haifeng
Liu, Renyuan
Qin, Ruomeng
Luo, Caimei
Li, Mengchun
Xu, Yun
Zhao, Hui
Bai, Feng
author_facet Ye, Qing
Chen, Haifeng
Liu, Renyuan
Qin, Ruomeng
Luo, Caimei
Li, Mengchun
Xu, Yun
Zhao, Hui
Bai, Feng
author_sort Ye, Qing
collection PubMed
description Both episodic memory and executive function are impaired in amnestic mild cognitive impairment (aMCI) subjects, but it is unclear if these impairments are independent or interactive. The present study aimed to explore the relationship between episodic memory deficits and executive function deficits, and the underlying functional mechanisms in aMCI subjects. Thirty-one aMCI subjects and 27 healthy subjects underwent neuropsychological tests and multimodal magnetic resonance imaging (MRI) scans. Hippocampal networks and medial prefrontal cortex (MPFC) networks were identified based on resting-sate functional MRI (fMRI) data. AMCI subjects displayed lower episodic memory scores and executive function scores than control subjects, and the episodic memory scores were positively correlated with the executive function scores in aMCI subjects. Brain network analyses showed an interaction between the hippocampal networks and the MPFC networks, and the interaction was significantly associated with the episodic memory scores and the executive function scores. Notably, aMCI subjects displayed higher functional connectivity (FC) of the right hippocampal network with the right prefrontal cortex than did control subjects, but this difference disappeared when controlling for the MPFC networks. Furthermore, the effects of the MPFC networks on the hippocampal networks were significantly associated with the episodic memory scores in aMCI subjects. The present findings suggested that the episodic memory deficits in aMCI subjects could be partially underpinned by the modulation of the MPFC networks on the hippocampal networks.
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spelling pubmed-86357292021-12-02 Lateralized Contributions of Medial Prefrontal Cortex Network to Episodic Memory Deficits in Subjects With Amnestic Mild Cognitive Impairment Ye, Qing Chen, Haifeng Liu, Renyuan Qin, Ruomeng Luo, Caimei Li, Mengchun Xu, Yun Zhao, Hui Bai, Feng Front Aging Neurosci Aging Neuroscience Both episodic memory and executive function are impaired in amnestic mild cognitive impairment (aMCI) subjects, but it is unclear if these impairments are independent or interactive. The present study aimed to explore the relationship between episodic memory deficits and executive function deficits, and the underlying functional mechanisms in aMCI subjects. Thirty-one aMCI subjects and 27 healthy subjects underwent neuropsychological tests and multimodal magnetic resonance imaging (MRI) scans. Hippocampal networks and medial prefrontal cortex (MPFC) networks were identified based on resting-sate functional MRI (fMRI) data. AMCI subjects displayed lower episodic memory scores and executive function scores than control subjects, and the episodic memory scores were positively correlated with the executive function scores in aMCI subjects. Brain network analyses showed an interaction between the hippocampal networks and the MPFC networks, and the interaction was significantly associated with the episodic memory scores and the executive function scores. Notably, aMCI subjects displayed higher functional connectivity (FC) of the right hippocampal network with the right prefrontal cortex than did control subjects, but this difference disappeared when controlling for the MPFC networks. Furthermore, the effects of the MPFC networks on the hippocampal networks were significantly associated with the episodic memory scores in aMCI subjects. The present findings suggested that the episodic memory deficits in aMCI subjects could be partially underpinned by the modulation of the MPFC networks on the hippocampal networks. Frontiers Media S.A. 2021-11-17 /pmc/articles/PMC8635729/ /pubmed/34867283 http://dx.doi.org/10.3389/fnagi.2021.756241 Text en Copyright © 2021 Ye, Chen, Liu, Qin, Luo, Li, Xu, Zhao and Bai. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging Neuroscience
Ye, Qing
Chen, Haifeng
Liu, Renyuan
Qin, Ruomeng
Luo, Caimei
Li, Mengchun
Xu, Yun
Zhao, Hui
Bai, Feng
Lateralized Contributions of Medial Prefrontal Cortex Network to Episodic Memory Deficits in Subjects With Amnestic Mild Cognitive Impairment
title Lateralized Contributions of Medial Prefrontal Cortex Network to Episodic Memory Deficits in Subjects With Amnestic Mild Cognitive Impairment
title_full Lateralized Contributions of Medial Prefrontal Cortex Network to Episodic Memory Deficits in Subjects With Amnestic Mild Cognitive Impairment
title_fullStr Lateralized Contributions of Medial Prefrontal Cortex Network to Episodic Memory Deficits in Subjects With Amnestic Mild Cognitive Impairment
title_full_unstemmed Lateralized Contributions of Medial Prefrontal Cortex Network to Episodic Memory Deficits in Subjects With Amnestic Mild Cognitive Impairment
title_short Lateralized Contributions of Medial Prefrontal Cortex Network to Episodic Memory Deficits in Subjects With Amnestic Mild Cognitive Impairment
title_sort lateralized contributions of medial prefrontal cortex network to episodic memory deficits in subjects with amnestic mild cognitive impairment
topic Aging Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635729/
https://www.ncbi.nlm.nih.gov/pubmed/34867283
http://dx.doi.org/10.3389/fnagi.2021.756241
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