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Deep Learning Technology in Pathological Image Analysis of Breast Tissue

To explore the application value of the multilevel pyramid convolutional neural network (MPCNN) model based on convolutional neural network (CNN) in breast histopathology image analysis, in this study, based on CNN algorithm and softmax classifier (SMC), a sparse autoencoder (SAE) is introduced to o...

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Autores principales: Liu, Yanan, Wang, Xiaoyan, Li, Jingyu, Hao, Liguo, Zhao, Tianyu, Zou, He, Xu, Dongbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635881/
https://www.ncbi.nlm.nih.gov/pubmed/34868535
http://dx.doi.org/10.1155/2021/9610830
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author Liu, Yanan
Wang, Xiaoyan
Li, Jingyu
Hao, Liguo
Zhao, Tianyu
Zou, He
Xu, Dongbin
author_facet Liu, Yanan
Wang, Xiaoyan
Li, Jingyu
Hao, Liguo
Zhao, Tianyu
Zou, He
Xu, Dongbin
author_sort Liu, Yanan
collection PubMed
description To explore the application value of the multilevel pyramid convolutional neural network (MPCNN) model based on convolutional neural network (CNN) in breast histopathology image analysis, in this study, based on CNN algorithm and softmax classifier (SMC), a sparse autoencoder (SAE) is introduced to optimize it. The sliding window method is used to identify cells, and the CNN + SMC pathological image cell detection method is established. Furthermore, the local region active contour (LRAC) is introduced to optimize it and the LRAC fine segmentation model driven by local Gaussian distribution is established. On this basis, the sparse automatic encoder is further introduced to optimize it and the MPCNN model is established. The proposed algorithm is evaluated on the pathological image data set. The results showed that the Acc value, F value, and Re value of pathological cell detection of CNN + SMC algorithm were significantly higher than those of the other two algorithms (P < 0.05). The Dice, OL, Sen, and Spe values of pathological image regional segmentation of CNN algorithm were significantly higher than those of the other two algorithms, and the difference was statistically significant (P < 0.05). The accuracy, recall, and F-measure of the optimized CNN algorithm for detecting breast histopathological images were 85.25%, 89.27%, and 80.09%, respectively. In the two databases with segmentation standards, the segmentation accuracy of MPCNN is 55%, 73.1%, 78.8%, and 82.1%. In the deep convolution network model, the training time of the MPCNN algorithm is about 80 min. It shows that when the feature dimension is low, the feature map extracted by MPCNN is more effective than the traditional feature extraction method.
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spelling pubmed-86358812021-12-02 Deep Learning Technology in Pathological Image Analysis of Breast Tissue Liu, Yanan Wang, Xiaoyan Li, Jingyu Hao, Liguo Zhao, Tianyu Zou, He Xu, Dongbin J Healthc Eng Research Article To explore the application value of the multilevel pyramid convolutional neural network (MPCNN) model based on convolutional neural network (CNN) in breast histopathology image analysis, in this study, based on CNN algorithm and softmax classifier (SMC), a sparse autoencoder (SAE) is introduced to optimize it. The sliding window method is used to identify cells, and the CNN + SMC pathological image cell detection method is established. Furthermore, the local region active contour (LRAC) is introduced to optimize it and the LRAC fine segmentation model driven by local Gaussian distribution is established. On this basis, the sparse automatic encoder is further introduced to optimize it and the MPCNN model is established. The proposed algorithm is evaluated on the pathological image data set. The results showed that the Acc value, F value, and Re value of pathological cell detection of CNN + SMC algorithm were significantly higher than those of the other two algorithms (P < 0.05). The Dice, OL, Sen, and Spe values of pathological image regional segmentation of CNN algorithm were significantly higher than those of the other two algorithms, and the difference was statistically significant (P < 0.05). The accuracy, recall, and F-measure of the optimized CNN algorithm for detecting breast histopathological images were 85.25%, 89.27%, and 80.09%, respectively. In the two databases with segmentation standards, the segmentation accuracy of MPCNN is 55%, 73.1%, 78.8%, and 82.1%. In the deep convolution network model, the training time of the MPCNN algorithm is about 80 min. It shows that when the feature dimension is low, the feature map extracted by MPCNN is more effective than the traditional feature extraction method. Hindawi 2021-11-24 /pmc/articles/PMC8635881/ /pubmed/34868535 http://dx.doi.org/10.1155/2021/9610830 Text en Copyright © 2021 Yanan Liu et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Liu, Yanan
Wang, Xiaoyan
Li, Jingyu
Hao, Liguo
Zhao, Tianyu
Zou, He
Xu, Dongbin
Deep Learning Technology in Pathological Image Analysis of Breast Tissue
title Deep Learning Technology in Pathological Image Analysis of Breast Tissue
title_full Deep Learning Technology in Pathological Image Analysis of Breast Tissue
title_fullStr Deep Learning Technology in Pathological Image Analysis of Breast Tissue
title_full_unstemmed Deep Learning Technology in Pathological Image Analysis of Breast Tissue
title_short Deep Learning Technology in Pathological Image Analysis of Breast Tissue
title_sort deep learning technology in pathological image analysis of breast tissue
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635881/
https://www.ncbi.nlm.nih.gov/pubmed/34868535
http://dx.doi.org/10.1155/2021/9610830
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