Branched ubiquitin chain binding and deubiquitination by UCH37 facilitate proteasome clearance of stress-induced inclusions

UCH37, also known as UCHL5, is a highly conserved deubiquitinating enzyme (DUB) that associates with the 26S proteasome. Recently, it was reported that UCH37 activity is stimulated by branched ubiquitin (Ub) chain architectures. To understand how UCH37 achieves its unique debranching specificity, we...

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Detalles Bibliográficos
Autores principales: Song, Aixin, Hazlett, Zachary, Abeykoon, Dulith, Dortch, Jeremy, Dillon, Andrew, Curtiss, Justin, Martinez, Sarah Bollinger, Hill, Christopher P, Yu, Clinton, Huang, Lan, Fushman, David, Cohen, Robert E, Yao, Tingting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635973/
https://www.ncbi.nlm.nih.gov/pubmed/34761751
http://dx.doi.org/10.7554/eLife.72798

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