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Markov state models of proton- and pore-dependent activation in a pentameric ligand-gated ion channel

Ligand-gated ion channels conduct currents in response to chemical stimuli, mediating electrochemical signaling in neurons and other excitable cells. For many channels, the details of gating remain unclear, partly due to limited structural data and simulation timescales. Here, we used enhanced sampl...

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Detalles Bibliográficos
Autores principales:	Bergh, Cathrine, Heusser, Stephanie A, Howard, Rebecca, Lindahl, Erik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Computational and Systems Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635979/ https://www.ncbi.nlm.nih.gov/pubmed/34652272 http://dx.doi.org/10.7554/eLife.68369

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