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Efficacy of FFP3 respirators for prevention of SARS-CoV-2 infection in healthcare workers

BACKGROUND: Respiratory protective equipment recommended in the UK for healthcare workers (HCWs) caring for patients with COVID-19 comprises a fluid-resistant surgical mask (FRSM), except in the context of aerosol generating procedures (AGPs). We previously demonstrated frequent pauci- and asymptoma...

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Autores principales: Ferris, Mark, Ferris, Rebecca, Workman, Chris, O'Connor, Eoin, Enoch, David A, Goldesgeyme, Emma, Quinnell, Natalie, Patel, Parth, Wright, Jo, Martell, Geraldine, Moody, Christine, Shaw, Ashley, Illingworth, Christopher JR, Matheson, Nicholas J, Weekes, Michael P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635983/
https://www.ncbi.nlm.nih.gov/pubmed/34783656
http://dx.doi.org/10.7554/eLife.71131
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author Ferris, Mark
Ferris, Rebecca
Workman, Chris
O'Connor, Eoin
Enoch, David A
Goldesgeyme, Emma
Quinnell, Natalie
Patel, Parth
Wright, Jo
Martell, Geraldine
Moody, Christine
Shaw, Ashley
Illingworth, Christopher JR
Matheson, Nicholas J
Weekes, Michael P
author_facet Ferris, Mark
Ferris, Rebecca
Workman, Chris
O'Connor, Eoin
Enoch, David A
Goldesgeyme, Emma
Quinnell, Natalie
Patel, Parth
Wright, Jo
Martell, Geraldine
Moody, Christine
Shaw, Ashley
Illingworth, Christopher JR
Matheson, Nicholas J
Weekes, Michael P
author_sort Ferris, Mark
collection PubMed
description BACKGROUND: Respiratory protective equipment recommended in the UK for healthcare workers (HCWs) caring for patients with COVID-19 comprises a fluid-resistant surgical mask (FRSM), except in the context of aerosol generating procedures (AGPs). We previously demonstrated frequent pauci- and asymptomatic severe acute respiratory syndrome coronavirus 2 infection HCWs during the first wave of the COVID-19 pandemic in the UK, using a comprehensive PCR-based HCW screening programme (Rivett et al., 2020; Jones et al., 2020). METHODS: Here, we use observational data and mathematical modelling to analyse infection rates amongst HCWs working on ‘red’ (coronavirus disease 2019, COVID-19) and ‘green’ (non-COVID-19) wards during the second wave of the pandemic, before and after the substitution of filtering face piece 3 (FFP3) respirators for FRSMs. RESULTS: Whilst using FRSMs, HCWs working on red wards faced an approximately 31-fold (and at least fivefold) increased risk of direct, ward-based infection. Conversely, after changing to FFP3 respirators, this risk was significantly reduced (52–100% protection). CONCLUSIONS: FFP3 respirators may therefore provide more effective protection than FRSMs for HCWs caring for patients with COVID-19, whether or not AGPs are undertaken. FUNDING: Wellcome Trust, Medical Research Council, Addenbrooke’s Charitable Trust, NIHR Cambridge Biomedical Research Centre, NHS Blood and Transfusion, UKRI.
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spelling pubmed-86359832021-12-03 Efficacy of FFP3 respirators for prevention of SARS-CoV-2 infection in healthcare workers Ferris, Mark Ferris, Rebecca Workman, Chris O'Connor, Eoin Enoch, David A Goldesgeyme, Emma Quinnell, Natalie Patel, Parth Wright, Jo Martell, Geraldine Moody, Christine Shaw, Ashley Illingworth, Christopher JR Matheson, Nicholas J Weekes, Michael P eLife Epidemiology and Global Health BACKGROUND: Respiratory protective equipment recommended in the UK for healthcare workers (HCWs) caring for patients with COVID-19 comprises a fluid-resistant surgical mask (FRSM), except in the context of aerosol generating procedures (AGPs). We previously demonstrated frequent pauci- and asymptomatic severe acute respiratory syndrome coronavirus 2 infection HCWs during the first wave of the COVID-19 pandemic in the UK, using a comprehensive PCR-based HCW screening programme (Rivett et al., 2020; Jones et al., 2020). METHODS: Here, we use observational data and mathematical modelling to analyse infection rates amongst HCWs working on ‘red’ (coronavirus disease 2019, COVID-19) and ‘green’ (non-COVID-19) wards during the second wave of the pandemic, before and after the substitution of filtering face piece 3 (FFP3) respirators for FRSMs. RESULTS: Whilst using FRSMs, HCWs working on red wards faced an approximately 31-fold (and at least fivefold) increased risk of direct, ward-based infection. Conversely, after changing to FFP3 respirators, this risk was significantly reduced (52–100% protection). CONCLUSIONS: FFP3 respirators may therefore provide more effective protection than FRSMs for HCWs caring for patients with COVID-19, whether or not AGPs are undertaken. FUNDING: Wellcome Trust, Medical Research Council, Addenbrooke’s Charitable Trust, NIHR Cambridge Biomedical Research Centre, NHS Blood and Transfusion, UKRI. eLife Sciences Publications, Ltd 2021-11-16 /pmc/articles/PMC8635983/ /pubmed/34783656 http://dx.doi.org/10.7554/eLife.71131 Text en © 2021, Ferris et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Epidemiology and Global Health
Ferris, Mark
Ferris, Rebecca
Workman, Chris
O'Connor, Eoin
Enoch, David A
Goldesgeyme, Emma
Quinnell, Natalie
Patel, Parth
Wright, Jo
Martell, Geraldine
Moody, Christine
Shaw, Ashley
Illingworth, Christopher JR
Matheson, Nicholas J
Weekes, Michael P
Efficacy of FFP3 respirators for prevention of SARS-CoV-2 infection in healthcare workers
title Efficacy of FFP3 respirators for prevention of SARS-CoV-2 infection in healthcare workers
title_full Efficacy of FFP3 respirators for prevention of SARS-CoV-2 infection in healthcare workers
title_fullStr Efficacy of FFP3 respirators for prevention of SARS-CoV-2 infection in healthcare workers
title_full_unstemmed Efficacy of FFP3 respirators for prevention of SARS-CoV-2 infection in healthcare workers
title_short Efficacy of FFP3 respirators for prevention of SARS-CoV-2 infection in healthcare workers
title_sort efficacy of ffp3 respirators for prevention of sars-cov-2 infection in healthcare workers
topic Epidemiology and Global Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635983/
https://www.ncbi.nlm.nih.gov/pubmed/34783656
http://dx.doi.org/10.7554/eLife.71131
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