Cargando…

Metabolites with SARS-CoV-2 Inhibitory Activity Identified from Human Microbiome Commensals

The COVID-19 pandemic has highlighted the need to identify additional antiviral small molecules to complement existing therapies. Although increasing evidence suggests that metabolites produced by the human microbiome have diverse biological activities, their antiviral properties remain poorly explo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Piscotta, Frank J., Hoffmann, Hans-Heinrich, Choi, Young Joo, Small, Gabriel I., Ashbrook, Alison W., Koirala, Bimal, Campbell, Elizabeth A., Darst, Seth A., Rice, Charles M., Brady, Sean F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8636105/ https://www.ncbi.nlm.nih.gov/pubmed/34851166 http://dx.doi.org/10.1128/mSphere.00711-21

Ejemplares similares

Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin
por: Braffman, Nathaniel R., et al.
Publicado: (2019)

Multiplexed functional metagenomic analysis of the infant microbiome identifies effectors of NF-κB, autophagy, and cellular redox state
por: Piscotta, Frank J., et al.
Publicado: (2021)

Contribution of Inhibitory Metabolites and Competition for Nutrients to Colonization Resistance against Clostridioides difficile by Commensal Clostridium
por: Reed, Amber D., et al.
Publicado: (2021)

Gut commensals and their metabolites in health and disease
por: Krishnamurthy, Hari Krishnan, et al.
Publicado: (2023)

On the effect of inheritance of microbes in commensal microbiomes
por: Zapién-Campos, Román, et al.
Publicado: (2022)

Integrated microbiome and metabolome analysis reveals a novel interplay between commensal bacteria and metabolites in colorectal cancer
por: Yang, Yongzhi, et al.
Publicado: (2019)

Metabolic Effects of Bovine Milk Oligosaccharides on Selected Commensals of the Infant Microbiome—Commensalism and Postbiotic Effects
por: Jakobsen, Louise M. A., et al.
Publicado: (2020)

Mapping Interactions of Microbial Metabolites with Human G-Protein-Coupled Receptors
por: Colosimo, Dominic A., et al.
Publicado: (2019)

Metabolites produced by commensal bacteria promote peripheral regulatory T cell generation
por: Arpaia, Nicholas, et al.
Publicado: (2013)

Commensal Microbiome Promotes Resistance to Local and Systemic Infections
por: Zhang, Nan, et al.
Publicado: (2015)

A survey of the sperm whale (Physeter catodon) commensal microbiome
por: Li, Chang, et al.
Publicado: (2019)

The Gut Commensal Microbiome of Drosophila melanogaster Is Modified by the Endosymbiont Wolbachia
por: Simhadri, Rama K., et al.
Publicado: (2017)

Emerging Function of Ecotype-Specific Splicing in the Recruitment of Commensal Microbiome
por: Li, Yue-Han, et al.
Publicado: (2022)

Characterization of Live-Attenuated Powassan Virus Vaccine Candidates Identifies an Efficacious Prime-Boost Strategy for Mitigating Powassan Virus Disease in a Murine Model
por: Cheung, Andrew M., et al.
Publicado: (2023)

Commensal-derived metabolites govern Vibrio cholerae pathogenesis in host intestine
por: You, Jin Sun, et al.
Publicado: (2019)

The Neuroprotective Effect of NEUROMIDE, a Compound Bioidentical to Commensal Bacteria Metabolites
por: Seo, Yoonhee, et al.
Publicado: (2022)

Antibiotic resistant bacteria and commensal fungi are common and conserved in the mosquito microbiome
por: Hyde, Josephine, et al.
Publicado: (2019)

Intestinal luminal putrescine is produced by collective biosynthetic pathways of the commensal microbiome
por: Nakamura, Atsuo, et al.
Publicado: (2018)

Improvement of Cecal Commensal Microbiome Following the Insect Additive into Chicken Diet
por: Józefiak, Agata, et al.
Publicado: (2020)

Rare transmission of commensal and pathogenic bacteria in the gut microbiome of hospitalized adults
por: Siranosian, Benjamin A., et al.
Publicado: (2022)

Structural and functional insights into the enzymatic plasticity of the SARS-CoV-2 NiRAN Domain
por: Small, Gabriel I., et al.
Publicado: (2023)

Comparison of Healthy and Dandruff Scalp Microbiome Reveals the Role of Commensals in Scalp Health
por: Saxena, Rituja, et al.
Publicado: (2018)

Dynamics of microbial competition, commensalism, and cooperation and its implications for coculture and microbiome engineering
por: Xu, Peng
Publicado: (2020)

The Function and Molecular Mechanism of Commensal Microbiome in Promoting Malignant Progression of Lung Cancer
por: Wang, Haiyang, et al.
Publicado: (2022)

Biosynthetic Interrogation of Soil Metagenomes Reveals Metamarin, an Uncommon Cyclomarin Congener with Activity against Mycobacterium tuberculosis
por: Li, Lei, et al.
Publicado: (2021)

Integrated microbiome, metabolome, and proteome analysis identifies a novel interplay among commensal bacteria, metabolites and candidate targets in non‐small cell lung cancer
por: Qian, Xiang, et al.
Publicado: (2022)

Longitudinal study of the scalp microbiome suggests coconut oil to enrich healthy scalp commensals
por: Saxena, Rituja, et al.
Publicado: (2021)

Commensal Bacteria in the Cystic Fibrosis Airway Microbiome Reduce P. aeruginosa Induced Inflammation
por: Tony-Odigie, Andrew, et al.
Publicado: (2022)

Commensal oral microbiota induces osteoimmunomodulatory effects separate from systemic microbiome in mice
por: Hathaway-Schrader, Jessica D., et al.
Publicado: (2022)

CoV-er all the bases: Structural perspectives of SARS-CoV-2 RNA synthesis
por: Malone, Brandon, et al.
Publicado: (2021)

Identification of structurally diverse menaquinone-binding antibiotics with in vivo activity against multidrug-resistant pathogens
por: Li, Lei, et al.
Publicado: (2021)

On Commensalism of Candida
por: Romo, Jesus A., et al.
Publicado: (2020)

Commensal bacterial metabolites may strengthen the effect of anti-IL6 treatment for COVID-19
por: Chen, Jiezhong, et al.
Publicado: (2021)

Probiotics and Commensal Bacteria Metabolites Trigger Epigenetic Changes in the Gut and Influence Beneficial Mood Dispositions
por: Vitetta, Luis, et al.
Publicado: (2023)

Combining Citizen Science and Genomics to Investigate Tick, Pathogen, and Commensal Microbiome at Single-Tick Resolution
por: Chauhan, Gaurav, et al.
Publicado: (2020)

Bruton’s Tyrosine Kinase Supports Gut Mucosal Immunity and Commensal Microbiome Recognition in Autoimmune Arthritis
por: Bonami, Rachel H., et al.
Publicado: (2022)

SARS-CoV-2 infection reduces human nasopharyngeal commensal microbiome with inclusion of pathobionts
por: Hoque, M. Nazmul, et al.
Publicado: (2021)

Microbiome Metabolites and Thyroid Dysfunction
por: Bargiel, Piotr, et al.
Publicado: (2021)

Commensal Microbiota and Cancer Immunotherapy: Harnessing Commensal Bacteria for Cancer Therapy
por: Bae, Jihong, et al.
Publicado: (2022)

Commensal Microbiome Expands Tγδ17 Cells in the Lung and Promotes Particulate Matter-Induced Acute Neutrophilia
por: Yang, Chorong, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_nrn47coo8u0kqhi29c6p9ilm6j