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Molecular Strategies to Target Protein Aggregation in Huntington’s Disease

Huntington’s disease (HD) is a neurodegenerative disorder caused by the aggregation of the mutant huntingtin (mHTT) protein in nerve cells. mHTT self-aggregates to form soluble oligomers and insoluble fibrils, which interfere in a number of key cellular functions. This leads to cell quiescence and u...

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Detalles Bibliográficos
Autores principales:	Jarosińska, Olga D., Rüdiger, Stefan G. D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8636123/ https://www.ncbi.nlm.nih.gov/pubmed/34869596 http://dx.doi.org/10.3389/fmolb.2021.769184

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