Predicting genotoxicity of viral vectors for stem cell gene therapy using gene expression-based machine learning

Hematopoietic stem cell gene therapy is emerging as a promising therapeutic strategy for many diseases of the blood and immune system. However, several individuals who underwent gene therapy in different trials developed hematological malignancies caused by insertional mutagenesis. Preclinical asses...

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Detalles Bibliográficos
Autores principales: Schwarzer, Adrian, Talbot, Steven R., Selich, Anton, Morgan, Michael, Schott, Juliane W., Dittrich-Breiholz, Oliver, Bastone, Antonella L., Weigel, Bettina, Ha, Teng Cheong, Dziadek, Violetta, Gijsbers, Rik, Thrasher, Adrian J., Staal, Frank J.T., Gaspar, Hubert B., Modlich, Ute, Schambach, Axel, Rothe, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8636173/
https://www.ncbi.nlm.nih.gov/pubmed/34174440
http://dx.doi.org/10.1016/j.ymthe.2021.06.017

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