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Gut microbiota is associated with bone mineral density: an observational and genome-wide environmental interaction analysis in the UK Biobank cohort

AIMS: Despite the interest in the association of gut microbiota with bone health, limited population-based studies of gut microbiota and bone mineral density (BMD) have been made. Our aim is to explore the possible association between gut microbiota and BMD. METHODS: A total of 3,321 independent loc...

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Autores principales: Cheng, Bolun, Wen, Yan, Yang, Xuena, Cheng, Shiqiang, Liu, Li, Chu, Xiaomeng, Ye, Jing, Liang, Chujun, Yao, Yao, Jia, Yumeng, Zhang, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The British Editorial Society of Bone & Joint Surgery 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8636179/
https://www.ncbi.nlm.nih.gov/pubmed/34779240
http://dx.doi.org/10.1302/2046-3758.1011.BJR-2021-0181.R1
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author Cheng, Bolun
Wen, Yan
Yang, Xuena
Cheng, Shiqiang
Liu, Li
Chu, Xiaomeng
Ye, Jing
Liang, Chujun
Yao, Yao
Jia, Yumeng
Zhang, Feng
author_facet Cheng, Bolun
Wen, Yan
Yang, Xuena
Cheng, Shiqiang
Liu, Li
Chu, Xiaomeng
Ye, Jing
Liang, Chujun
Yao, Yao
Jia, Yumeng
Zhang, Feng
author_sort Cheng, Bolun
collection PubMed
description AIMS: Despite the interest in the association of gut microbiota with bone health, limited population-based studies of gut microbiota and bone mineral density (BMD) have been made. Our aim is to explore the possible association between gut microbiota and BMD. METHODS: A total of 3,321 independent loci of gut microbiota were used to calculate the individual polygenic risk score (PRS) for 114 gut microbiota-related traits. The individual genotype data were obtained from UK Biobank cohort. Linear regressions were then conducted to evaluate the possible association of gut microbiota with L1-L4 BMD (n = 4,070), total BMD (n = 4,056), and femur total BMD (n = 4,054), respectively. PLINK 2.0 was used to detect the single-nucleotide polymorphism (SNP) × gut microbiota interaction effect on the risks of L1-L4 BMD, total BMD, and femur total BMD, respectively. RESULTS: We detected five, three, and seven candidate gut microbiota-related traits for L1-L4 BMD, total BMD, and femur BMD, respectively, such as genus Dialister (p = 0.004) for L1-L4 BMD, and genus Eisenbergiella (p = 0.046) for total BMD. We also detected two common gut microbiota-related traits shared by L1-L4 BMD, total BMD, and femur total BMD, including genus Escherichia Shigella and genus Lactococcus. Interaction analysis of BMD detected several genes that interacted with gut microbiota, such as phospholipase D1 (PLD1) and endomucin (EMCN) interacting with genus Dialister in total BMD, and COL12A1 and Discs Large MAGUK Scaffold Protein 2 (DLG2) interacting with genus Lactococcus in femur BMD. CONCLUSION: Our results suggest associations between gut microbiota and BMD, which will be helpful to further explore the regulation mechanism and intervention gut microbiota of BMD. Cite this article: Bone Joint Res 2021;10(11):734–741.
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spelling pubmed-86361792021-12-17 Gut microbiota is associated with bone mineral density: an observational and genome-wide environmental interaction analysis in the UK Biobank cohort Cheng, Bolun Wen, Yan Yang, Xuena Cheng, Shiqiang Liu, Li Chu, Xiaomeng Ye, Jing Liang, Chujun Yao, Yao Jia, Yumeng Zhang, Feng Bone Joint Res Bone Biology AIMS: Despite the interest in the association of gut microbiota with bone health, limited population-based studies of gut microbiota and bone mineral density (BMD) have been made. Our aim is to explore the possible association between gut microbiota and BMD. METHODS: A total of 3,321 independent loci of gut microbiota were used to calculate the individual polygenic risk score (PRS) for 114 gut microbiota-related traits. The individual genotype data were obtained from UK Biobank cohort. Linear regressions were then conducted to evaluate the possible association of gut microbiota with L1-L4 BMD (n = 4,070), total BMD (n = 4,056), and femur total BMD (n = 4,054), respectively. PLINK 2.0 was used to detect the single-nucleotide polymorphism (SNP) × gut microbiota interaction effect on the risks of L1-L4 BMD, total BMD, and femur total BMD, respectively. RESULTS: We detected five, three, and seven candidate gut microbiota-related traits for L1-L4 BMD, total BMD, and femur BMD, respectively, such as genus Dialister (p = 0.004) for L1-L4 BMD, and genus Eisenbergiella (p = 0.046) for total BMD. We also detected two common gut microbiota-related traits shared by L1-L4 BMD, total BMD, and femur total BMD, including genus Escherichia Shigella and genus Lactococcus. Interaction analysis of BMD detected several genes that interacted with gut microbiota, such as phospholipase D1 (PLD1) and endomucin (EMCN) interacting with genus Dialister in total BMD, and COL12A1 and Discs Large MAGUK Scaffold Protein 2 (DLG2) interacting with genus Lactococcus in femur BMD. CONCLUSION: Our results suggest associations between gut microbiota and BMD, which will be helpful to further explore the regulation mechanism and intervention gut microbiota of BMD. Cite this article: Bone Joint Res 2021;10(11):734–741. The British Editorial Society of Bone & Joint Surgery 2021-11-15 /pmc/articles/PMC8636179/ /pubmed/34779240 http://dx.doi.org/10.1302/2046-3758.1011.BJR-2021-0181.R1 Text en © 2021 Author(s) et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (CC BY-NC-ND 4.0) licence, which permits the copying and redistribution of the work only, and provided the original author and source are credited. See https://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Bone Biology
Cheng, Bolun
Wen, Yan
Yang, Xuena
Cheng, Shiqiang
Liu, Li
Chu, Xiaomeng
Ye, Jing
Liang, Chujun
Yao, Yao
Jia, Yumeng
Zhang, Feng
Gut microbiota is associated with bone mineral density: an observational and genome-wide environmental interaction analysis in the UK Biobank cohort
title Gut microbiota is associated with bone mineral density: an observational and genome-wide environmental interaction analysis in the UK Biobank cohort
title_full Gut microbiota is associated with bone mineral density: an observational and genome-wide environmental interaction analysis in the UK Biobank cohort
title_fullStr Gut microbiota is associated with bone mineral density: an observational and genome-wide environmental interaction analysis in the UK Biobank cohort
title_full_unstemmed Gut microbiota is associated with bone mineral density: an observational and genome-wide environmental interaction analysis in the UK Biobank cohort
title_short Gut microbiota is associated with bone mineral density: an observational and genome-wide environmental interaction analysis in the UK Biobank cohort
title_sort gut microbiota is associated with bone mineral density: an observational and genome-wide environmental interaction analysis in the uk biobank cohort
topic Bone Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8636179/
https://www.ncbi.nlm.nih.gov/pubmed/34779240
http://dx.doi.org/10.1302/2046-3758.1011.BJR-2021-0181.R1
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