Overcoming target epitope masking resistance that can occur on low-antigen-expresser AML blasts after IL-1RAP chimeric antigen receptor T cell therapy using the inducible caspase 9 suicide gene safety switch

Although chimeric antigen receptor CAR) T cell immunotherapies are an undeniable and unequivocal success, knowledge obtained from the monitoring of the first clinical trials targeting the CD19 antigen in B malignancies, either refractory/relapsed acute lymphoid leukemia (ALL) or lymphomas, contribut...

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Detalles Bibliográficos
Autores principales: Warda, Walid, Da Rocha, Mathieu Neto, Trad, Rim, Haderbache, Rafik, Salma, Yahya, Bouquet, Lucie, Roussel, Xavier, Nicod, Clémentine, Deschamps, Marina, Ferrand, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8636256/
https://www.ncbi.nlm.nih.gov/pubmed/33414517
http://dx.doi.org/10.1038/s41417-020-00284-3

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