Transcriptional activators YAP/TAZ and AXL orchestrate dedifferentiation, cell fate, and metastasis in human osteosarcoma

Osteosarcoma (OS) is a molecularly heterogeneous, aggressive, poorly differentiated pediatric bone cancer that frequently spreads to the lung. Relatively little is known about phenotypic and epigenetic changes that promote lung metastases. To identify key drivers of metastasis, we studied human CCH-...

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Detalles Bibliográficos
Autores principales: Lamhamedi-Cherradi, Salah-Eddine, Mohiuddin, Sana, Mishra, Dhruva K., Krishnan, Sandhya, Velasco, Alejandra Ruiz, Vetter, Amelia M., Pence, Kristi, McCall, David, Truong, Danh D., Cuglievan, Branko, Menegaz, Brian A., Utama, Budi, Daw, Najat C., Molina, Eric R., Zielinski, Rafal J., Livingston, John A., Gorlick, Richard, Mikos, Antonios G., Kim, Min P., Ludwig, Joseph A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8636268/
https://www.ncbi.nlm.nih.gov/pubmed/33408328
http://dx.doi.org/10.1038/s41417-020-00281-6

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