Emergence of mTOR mutation as an acquired resistance mechanism to AKT inhibition, and subsequent response to mTORC1/2 inhibition

Acquired resistance to molecular targeted therapy is a significant challenge of the precision medicine era. The ability to understand these mechanisms of resistance may improve patient selection and allow for the development of rationally designed next-line or combination treatment strategies and im...

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Detalles Bibliográficos
Autores principales: Coleman, Niamh, Subbiah, Vivek, Pant, Shubham, Patel, Keyur, Roy-Chowdhuri, Sinchita, Yedururi, Sireesha, Johnson, Amber, Yap, Timothy A., Rodon, Jordi, Shaw, Kenna, Meric-Bernstam, Funda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8636467/
https://www.ncbi.nlm.nih.gov/pubmed/34853384
http://dx.doi.org/10.1038/s41698-021-00240-w

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