A point-mutation in the C-domain of CMP-sialic acid synthetase leads to lethality of medaka due to protein insolubility

Vertebrate CMP-sialic acid synthetase (CSS), which catalyzes the synthesis of CMP-sialic acid (CMP-Sia), consists of a 28 kDa-N-domain and a 20 kDa-C-domain. The N-domain is known to be a catalytic domain; however, the significance of the C-domain still remains unknown. To elucidate the function of...

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Detalles Bibliográficos
Autores principales: Wu, Di, Arakawa, Hiromu, Fujita, Akiko, Hashimoto, Hisashi, Hibi, Masahiko, Naruse, Kiyoshi, Kamei, Yasuhiro, Sato, Chihiro, Kitajima, Ken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8636478/
https://www.ncbi.nlm.nih.gov/pubmed/34853329
http://dx.doi.org/10.1038/s41598-021-01715-3

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