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Development of a new risk stratification system for patients with newly diagnosed multiple myeloma using R-ISS and (18)F-FDG PET/CT

In multiple myeloma (MM), a high number of focal lesions (FL) detected using positron emission tomography/computed tomography (PET/CT) was found to be associated with adverse prognosis. To design a new risk stratification system that combines the Revised International Staging System (R-ISS) with FL,...

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Autores principales: Cho, Hee Jeong, Jung, Sung-Hoon, Jo, Jae-Cheol, Lee, Yoo Jin, Yoon, Sang Eun, Park, Sung-Soo, Kim, Do Young, Shin, Ho-Jin, Mun, Yeung-Chul, Yi, Jun Ho, Kim, Hyo Jung, Kim, Da Jung, Lee, Ho Sup, Bae, Sung Hwa, Hong, Chae Moon, Jeong, Shin Young, Min, Jung-Joon, Sohn, Sang Kyun, Min, Chang-Ki, Kim, Kihyun, Lee, Je-Jung, Moon, Joon Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8636569/
https://www.ncbi.nlm.nih.gov/pubmed/34853295
http://dx.doi.org/10.1038/s41408-021-00577-2
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author Cho, Hee Jeong
Jung, Sung-Hoon
Jo, Jae-Cheol
Lee, Yoo Jin
Yoon, Sang Eun
Park, Sung-Soo
Kim, Do Young
Shin, Ho-Jin
Mun, Yeung-Chul
Yi, Jun Ho
Kim, Hyo Jung
Kim, Da Jung
Lee, Ho Sup
Bae, Sung Hwa
Hong, Chae Moon
Jeong, Shin Young
Min, Jung-Joon
Sohn, Sang Kyun
Min, Chang-Ki
Kim, Kihyun
Lee, Je-Jung
Moon, Joon Ho
author_facet Cho, Hee Jeong
Jung, Sung-Hoon
Jo, Jae-Cheol
Lee, Yoo Jin
Yoon, Sang Eun
Park, Sung-Soo
Kim, Do Young
Shin, Ho-Jin
Mun, Yeung-Chul
Yi, Jun Ho
Kim, Hyo Jung
Kim, Da Jung
Lee, Ho Sup
Bae, Sung Hwa
Hong, Chae Moon
Jeong, Shin Young
Min, Jung-Joon
Sohn, Sang Kyun
Min, Chang-Ki
Kim, Kihyun
Lee, Je-Jung
Moon, Joon Ho
author_sort Cho, Hee Jeong
collection PubMed
description In multiple myeloma (MM), a high number of focal lesions (FL) detected using positron emission tomography/computed tomography (PET/CT) was found to be associated with adverse prognosis. To design a new risk stratification system that combines the Revised International Staging System (R-ISS) with FL, we analyzed the data of 380 patients with newly diagnosed MM (NDMM) who underwent (18)F-fluorodeoxyglucose ((18)F-FDG) PET/CT upon diagnosis. The K-adaptive partitioning algorithm was adopted to define subgroups with homogeneous survival. The combined R-ISS with PET/CT classified NDMM patients into four groups: R-ISS/PET stage I (n = 31; R-ISS I with FL ≤ 3), stage II (n = 156; R-ISS I with FL > 3 and R-ISS II with FL ≤ 3), stage III (n = 162; R-ISS II with FL > 3 and R-ISS III with FL ≤ 3), and stage IV (n = 31; R-ISS III with FL > 3). The 2-year overall survival rates for stages I, II, III, and IV were 96.7%, 89.8%, 74.7%, and 50.3%. The 2-year progression-free survival rates were 84.1%, 64.7%, 40.8%, and 17.1%, respectively. The new R-ISS/PET was successfully validated in an external cohort. This new system had a remarkable prognostic power for estimating the survival outcomes of patients with NDMM. This system helps discriminate patients with a good prognosis from those with a poor prognosis more precisely.
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spelling pubmed-86365692021-12-15 Development of a new risk stratification system for patients with newly diagnosed multiple myeloma using R-ISS and (18)F-FDG PET/CT Cho, Hee Jeong Jung, Sung-Hoon Jo, Jae-Cheol Lee, Yoo Jin Yoon, Sang Eun Park, Sung-Soo Kim, Do Young Shin, Ho-Jin Mun, Yeung-Chul Yi, Jun Ho Kim, Hyo Jung Kim, Da Jung Lee, Ho Sup Bae, Sung Hwa Hong, Chae Moon Jeong, Shin Young Min, Jung-Joon Sohn, Sang Kyun Min, Chang-Ki Kim, Kihyun Lee, Je-Jung Moon, Joon Ho Blood Cancer J Article In multiple myeloma (MM), a high number of focal lesions (FL) detected using positron emission tomography/computed tomography (PET/CT) was found to be associated with adverse prognosis. To design a new risk stratification system that combines the Revised International Staging System (R-ISS) with FL, we analyzed the data of 380 patients with newly diagnosed MM (NDMM) who underwent (18)F-fluorodeoxyglucose ((18)F-FDG) PET/CT upon diagnosis. The K-adaptive partitioning algorithm was adopted to define subgroups with homogeneous survival. The combined R-ISS with PET/CT classified NDMM patients into four groups: R-ISS/PET stage I (n = 31; R-ISS I with FL ≤ 3), stage II (n = 156; R-ISS I with FL > 3 and R-ISS II with FL ≤ 3), stage III (n = 162; R-ISS II with FL > 3 and R-ISS III with FL ≤ 3), and stage IV (n = 31; R-ISS III with FL > 3). The 2-year overall survival rates for stages I, II, III, and IV were 96.7%, 89.8%, 74.7%, and 50.3%. The 2-year progression-free survival rates were 84.1%, 64.7%, 40.8%, and 17.1%, respectively. The new R-ISS/PET was successfully validated in an external cohort. This new system had a remarkable prognostic power for estimating the survival outcomes of patients with NDMM. This system helps discriminate patients with a good prognosis from those with a poor prognosis more precisely. Nature Publishing Group UK 2021-12-01 /pmc/articles/PMC8636569/ /pubmed/34853295 http://dx.doi.org/10.1038/s41408-021-00577-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Cho, Hee Jeong
Jung, Sung-Hoon
Jo, Jae-Cheol
Lee, Yoo Jin
Yoon, Sang Eun
Park, Sung-Soo
Kim, Do Young
Shin, Ho-Jin
Mun, Yeung-Chul
Yi, Jun Ho
Kim, Hyo Jung
Kim, Da Jung
Lee, Ho Sup
Bae, Sung Hwa
Hong, Chae Moon
Jeong, Shin Young
Min, Jung-Joon
Sohn, Sang Kyun
Min, Chang-Ki
Kim, Kihyun
Lee, Je-Jung
Moon, Joon Ho
Development of a new risk stratification system for patients with newly diagnosed multiple myeloma using R-ISS and (18)F-FDG PET/CT
title Development of a new risk stratification system for patients with newly diagnosed multiple myeloma using R-ISS and (18)F-FDG PET/CT
title_full Development of a new risk stratification system for patients with newly diagnosed multiple myeloma using R-ISS and (18)F-FDG PET/CT
title_fullStr Development of a new risk stratification system for patients with newly diagnosed multiple myeloma using R-ISS and (18)F-FDG PET/CT
title_full_unstemmed Development of a new risk stratification system for patients with newly diagnosed multiple myeloma using R-ISS and (18)F-FDG PET/CT
title_short Development of a new risk stratification system for patients with newly diagnosed multiple myeloma using R-ISS and (18)F-FDG PET/CT
title_sort development of a new risk stratification system for patients with newly diagnosed multiple myeloma using r-iss and (18)f-fdg pet/ct
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8636569/
https://www.ncbi.nlm.nih.gov/pubmed/34853295
http://dx.doi.org/10.1038/s41408-021-00577-2
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