Amantadine inhibits known and novel ion channels encoded by SARS-CoV-2 in vitro

The dire need for COVID-19 treatments has inspired strategies of repurposing approved drugs. Amantadine has been suggested as a candidate, and cellular as well as clinical studies have indicated beneficial effects of this drug. We demonstrate that amantadine and hexamethylene-amiloride (HMA), but no...

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Detalles Bibliográficos
Autores principales: Toft-Bertelsen, Trine Lisberg, Jeppesen, Mads Gravers, Tzortzini, Eva, Xue, Kai, Giller, Karin, Becker, Stefan, Mujezinovic, Amer, Bentzen, Bo Hjorth, B. Andreas, Loren, Kolocouris, Antonios, Kledal, Thomas Nitschke, Rosenkilde, Mette Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8636635/
https://www.ncbi.nlm.nih.gov/pubmed/34853399
http://dx.doi.org/10.1038/s42003-021-02866-9

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