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Exosomes: Small vesicles with big roles in cancer, vaccine development, and therapeutics
Cancer is a deadly disease that is globally and consistently one of the leading causes of mortality every year. Despite the availability of chemotherapy, radiotherapy, immunotherapy, and surgery, a cure for cancer has not been attained. Recently, exosomes have gained significant attention due to the...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
KeAi Publishing
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8636666/ https://www.ncbi.nlm.nih.gov/pubmed/34901546 http://dx.doi.org/10.1016/j.bioactmat.2021.08.029 |
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author | Thakur, Abhimanyu Parra, Diana Carolina Motallebnejad, Pedram Brocchi, Marcelo Chen, Huanhuan Joyce |
author_facet | Thakur, Abhimanyu Parra, Diana Carolina Motallebnejad, Pedram Brocchi, Marcelo Chen, Huanhuan Joyce |
author_sort | Thakur, Abhimanyu |
collection | PubMed |
description | Cancer is a deadly disease that is globally and consistently one of the leading causes of mortality every year. Despite the availability of chemotherapy, radiotherapy, immunotherapy, and surgery, a cure for cancer has not been attained. Recently, exosomes have gained significant attention due to the therapeutic potential of their various components including proteins, lipids, nucleic acids, miRNAs, and lncRNAs. Exosomes constitute a set of tiny extracellular vesicles with an approximate diameter of 30–100 nm. They are released from different cells and are present in biofluids including blood, cerebrospinal fluid (CSF), and urine. They perform crucial multifaceted functions in the malignant progression of cancer via autocrine, paracrine, and endocrine communications. The ability of exosomes to carry different cargoes including drug and molecular information to recipient cells make them a novel tool for cancer therapeutics. In this review, we discuss the major components of exosomes and their role in cancer progression. We also review important literature about the potential role of exosomes as vaccines and delivery carriers in the context of cancer therapeutics. |
format | Online Article Text |
id | pubmed-8636666 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | KeAi Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-86366662021-12-09 Exosomes: Small vesicles with big roles in cancer, vaccine development, and therapeutics Thakur, Abhimanyu Parra, Diana Carolina Motallebnejad, Pedram Brocchi, Marcelo Chen, Huanhuan Joyce Bioact Mater Article Cancer is a deadly disease that is globally and consistently one of the leading causes of mortality every year. Despite the availability of chemotherapy, radiotherapy, immunotherapy, and surgery, a cure for cancer has not been attained. Recently, exosomes have gained significant attention due to the therapeutic potential of their various components including proteins, lipids, nucleic acids, miRNAs, and lncRNAs. Exosomes constitute a set of tiny extracellular vesicles with an approximate diameter of 30–100 nm. They are released from different cells and are present in biofluids including blood, cerebrospinal fluid (CSF), and urine. They perform crucial multifaceted functions in the malignant progression of cancer via autocrine, paracrine, and endocrine communications. The ability of exosomes to carry different cargoes including drug and molecular information to recipient cells make them a novel tool for cancer therapeutics. In this review, we discuss the major components of exosomes and their role in cancer progression. We also review important literature about the potential role of exosomes as vaccines and delivery carriers in the context of cancer therapeutics. KeAi Publishing 2021-08-28 /pmc/articles/PMC8636666/ /pubmed/34901546 http://dx.doi.org/10.1016/j.bioactmat.2021.08.029 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Thakur, Abhimanyu Parra, Diana Carolina Motallebnejad, Pedram Brocchi, Marcelo Chen, Huanhuan Joyce Exosomes: Small vesicles with big roles in cancer, vaccine development, and therapeutics |
title | Exosomes: Small vesicles with big roles in cancer, vaccine development, and therapeutics |
title_full | Exosomes: Small vesicles with big roles in cancer, vaccine development, and therapeutics |
title_fullStr | Exosomes: Small vesicles with big roles in cancer, vaccine development, and therapeutics |
title_full_unstemmed | Exosomes: Small vesicles with big roles in cancer, vaccine development, and therapeutics |
title_short | Exosomes: Small vesicles with big roles in cancer, vaccine development, and therapeutics |
title_sort | exosomes: small vesicles with big roles in cancer, vaccine development, and therapeutics |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8636666/ https://www.ncbi.nlm.nih.gov/pubmed/34901546 http://dx.doi.org/10.1016/j.bioactmat.2021.08.029 |
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