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24-Hour Profiles of 11-Oxygenated C(19) Steroids and Δ(5)-Steroid Sulfates during Oral and Continuous Subcutaneous Glucocorticoids in 21-Hydroxylase Deficiency

BACKGROUND: Optimal management of androgen excess in 21-hydroxylase deficiency (21OHD) remains challenging. 11-oxygenated-C(19) steroids (11-oxyandrogens) have emerged as promising biomarkers of disease control, but data regarding their response to treatment are lacking. OBJECTIVE: To compare the dy...

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Detalles Bibliográficos
Autores principales: Turcu, Adina F., Mallappa, Ashwini, Nella, Aikaterini A., Chen, Xuan, Zhao, Lili, Nanba, Aya T., Byrd, James Brian, Auchus, Richard J., Merke, Deborah P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8636728/
https://www.ncbi.nlm.nih.gov/pubmed/34867794
http://dx.doi.org/10.3389/fendo.2021.751191