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Association between the Use of Diuretics and Size Reduction in Pediatric Atrial Septal Defect
BACKGROUND AND OBJECTIVES: While diuretics are sometimes used in atrial septal defect (ASD) treatment, their effect on ASD size reduction remains unclear. We aimed to evaluate the efficacy of diuretics in ASD size reduction in pediatric patients. METHODS: We retrospectively reviewed the medical reco...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society of Cardiology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8636757/ https://www.ncbi.nlm.nih.gov/pubmed/34595884 http://dx.doi.org/10.4070/kcj.2021.0076 |
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author | Lee, Jue Seong Kim, Gi Beom Lee, Won Jung Song, Seok Hyun An, Hyo Soon Lee, Sang Yun Song, Mi Kyoung Kwon, Hye Won Bae, Eun Jung |
author_facet | Lee, Jue Seong Kim, Gi Beom Lee, Won Jung Song, Seok Hyun An, Hyo Soon Lee, Sang Yun Song, Mi Kyoung Kwon, Hye Won Bae, Eun Jung |
author_sort | Lee, Jue Seong |
collection | PubMed |
description | BACKGROUND AND OBJECTIVES: While diuretics are sometimes used in atrial septal defect (ASD) treatment, their effect on ASD size reduction remains unclear. We aimed to evaluate the efficacy of diuretics in ASD size reduction in pediatric patients. METHODS: We retrospectively reviewed the medical records of patients with secundum ASD (size ≥10 mm), between 2005 and 2019. Patients were divided into two groups based on the diuretic administration. RESULTS: Of the 73 enrolled patients, 40 received diuretics. The initial age at ASD diagnosis (2.8±1.7 vs. 2.5±2.0 years, p=0.526) and follow-up duration (22.3±11.4 vs. 18.7±13.2 months, p=0.224) were not significantly different between the groups. The ASD diameter at the initial diagnosis (13.7±2.0 vs. 13.5±3.4 mm, p=0.761) and the indexed ASD diameter (25.5±5.9 vs. 26.9±10.3 mm/m(2), p=0.493) were also not significantly different between two groups. The ASD diameter significantly increased in the non-diuretic group during follow-up (0.0±2.9 vs. +2.6±2.0 mm, p<0.001). The indexed ASD diameter significantly decreased in the diuretic group during follow-up (−5.7±6.5 vs. +0.2±3.9 mm/m(2), p<0.001). In the linear mixed model analysis, diuretic use was associated with ASD diameter decrease (p<0.001) and indexed ASD diameter reduction (p<0.001) over time. Device closure was more frequently performed in the diuretic (75.0%) than in the non-diuretic group (39.4%). CONCLUSIONS: Patients receiving diuretics are less likely to undergo surgery. The diuretics administration may be associated with the use of smaller ASD devices for transcatheter treatment through ASD size reduction. |
format | Online Article Text |
id | pubmed-8636757 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Korean Society of Cardiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-86367572021-12-13 Association between the Use of Diuretics and Size Reduction in Pediatric Atrial Septal Defect Lee, Jue Seong Kim, Gi Beom Lee, Won Jung Song, Seok Hyun An, Hyo Soon Lee, Sang Yun Song, Mi Kyoung Kwon, Hye Won Bae, Eun Jung Korean Circ J Original Research BACKGROUND AND OBJECTIVES: While diuretics are sometimes used in atrial septal defect (ASD) treatment, their effect on ASD size reduction remains unclear. We aimed to evaluate the efficacy of diuretics in ASD size reduction in pediatric patients. METHODS: We retrospectively reviewed the medical records of patients with secundum ASD (size ≥10 mm), between 2005 and 2019. Patients were divided into two groups based on the diuretic administration. RESULTS: Of the 73 enrolled patients, 40 received diuretics. The initial age at ASD diagnosis (2.8±1.7 vs. 2.5±2.0 years, p=0.526) and follow-up duration (22.3±11.4 vs. 18.7±13.2 months, p=0.224) were not significantly different between the groups. The ASD diameter at the initial diagnosis (13.7±2.0 vs. 13.5±3.4 mm, p=0.761) and the indexed ASD diameter (25.5±5.9 vs. 26.9±10.3 mm/m(2), p=0.493) were also not significantly different between two groups. The ASD diameter significantly increased in the non-diuretic group during follow-up (0.0±2.9 vs. +2.6±2.0 mm, p<0.001). The indexed ASD diameter significantly decreased in the diuretic group during follow-up (−5.7±6.5 vs. +0.2±3.9 mm/m(2), p<0.001). In the linear mixed model analysis, diuretic use was associated with ASD diameter decrease (p<0.001) and indexed ASD diameter reduction (p<0.001) over time. Device closure was more frequently performed in the diuretic (75.0%) than in the non-diuretic group (39.4%). CONCLUSIONS: Patients receiving diuretics are less likely to undergo surgery. The diuretics administration may be associated with the use of smaller ASD devices for transcatheter treatment through ASD size reduction. The Korean Society of Cardiology 2021-08-31 /pmc/articles/PMC8636757/ /pubmed/34595884 http://dx.doi.org/10.4070/kcj.2021.0076 Text en Copyright © 2021. The Korean Society of Cardiology https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Lee, Jue Seong Kim, Gi Beom Lee, Won Jung Song, Seok Hyun An, Hyo Soon Lee, Sang Yun Song, Mi Kyoung Kwon, Hye Won Bae, Eun Jung Association between the Use of Diuretics and Size Reduction in Pediatric Atrial Septal Defect |
title | Association between the Use of Diuretics and Size Reduction in Pediatric Atrial Septal Defect |
title_full | Association between the Use of Diuretics and Size Reduction in Pediatric Atrial Septal Defect |
title_fullStr | Association between the Use of Diuretics and Size Reduction in Pediatric Atrial Septal Defect |
title_full_unstemmed | Association between the Use of Diuretics and Size Reduction in Pediatric Atrial Septal Defect |
title_short | Association between the Use of Diuretics and Size Reduction in Pediatric Atrial Septal Defect |
title_sort | association between the use of diuretics and size reduction in pediatric atrial septal defect |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8636757/ https://www.ncbi.nlm.nih.gov/pubmed/34595884 http://dx.doi.org/10.4070/kcj.2021.0076 |
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