Molecular Mechanisms of Memory Consolidation That Operate During Sleep

The role of sleep for brain function has been in the focus of interest for many years. It is now firmly established that sleep and the corresponding brain activity is of central importance for memory consolidation. Less clear are the underlying molecular mechanisms and their specific contribution to...

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Autores principales: Reyes-Resina, Irene, Samer, Sebastian, Kreutz, Michael R., Oelschlegel, Anja M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8636908/
https://www.ncbi.nlm.nih.gov/pubmed/34867190
http://dx.doi.org/10.3389/fnmol.2021.767384
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author Reyes-Resina, Irene
Samer, Sebastian
Kreutz, Michael R.
Oelschlegel, Anja M.
author_facet Reyes-Resina, Irene
Samer, Sebastian
Kreutz, Michael R.
Oelschlegel, Anja M.
author_sort Reyes-Resina, Irene
collection PubMed
description The role of sleep for brain function has been in the focus of interest for many years. It is now firmly established that sleep and the corresponding brain activity is of central importance for memory consolidation. Less clear are the underlying molecular mechanisms and their specific contribution to the formation of long-term memory. In this review, we summarize the current knowledge of such mechanisms and we discuss the several unknowns that hinder a deeper appreciation of how molecular mechanisms of memory consolidation during sleep impact synaptic function and engram formation.
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spelling pubmed-86369082021-12-03 Molecular Mechanisms of Memory Consolidation That Operate During Sleep Reyes-Resina, Irene Samer, Sebastian Kreutz, Michael R. Oelschlegel, Anja M. Front Mol Neurosci Molecular Neuroscience The role of sleep for brain function has been in the focus of interest for many years. It is now firmly established that sleep and the corresponding brain activity is of central importance for memory consolidation. Less clear are the underlying molecular mechanisms and their specific contribution to the formation of long-term memory. In this review, we summarize the current knowledge of such mechanisms and we discuss the several unknowns that hinder a deeper appreciation of how molecular mechanisms of memory consolidation during sleep impact synaptic function and engram formation. Frontiers Media S.A. 2021-11-18 /pmc/articles/PMC8636908/ /pubmed/34867190 http://dx.doi.org/10.3389/fnmol.2021.767384 Text en Copyright © 2021 Reyes-Resina, Samer, Kreutz and Oelschlegel. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Neuroscience
Reyes-Resina, Irene
Samer, Sebastian
Kreutz, Michael R.
Oelschlegel, Anja M.
Molecular Mechanisms of Memory Consolidation That Operate During Sleep
title Molecular Mechanisms of Memory Consolidation That Operate During Sleep
title_full Molecular Mechanisms of Memory Consolidation That Operate During Sleep
title_fullStr Molecular Mechanisms of Memory Consolidation That Operate During Sleep
title_full_unstemmed Molecular Mechanisms of Memory Consolidation That Operate During Sleep
title_short Molecular Mechanisms of Memory Consolidation That Operate During Sleep
title_sort molecular mechanisms of memory consolidation that operate during sleep
topic Molecular Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8636908/
https://www.ncbi.nlm.nih.gov/pubmed/34867190
http://dx.doi.org/10.3389/fnmol.2021.767384
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