The steroidal lactone withaferin A impedes T-cell motility by inhibiting the kinase ZAP70 and subsequent kinome signaling

The steroidal lactone withaferin A (WFA) is a dietary phytochemical, derived from Withania somnifera. It exhibits a wide range of biological properties, including immunomodulatory, anti-inflammatory, antistress, and anticancer activities. Here we investigated the effect of WFA on T-cell motility, wh...

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Detalles Bibliográficos
Autores principales: Fazil, Mobashar Hussain Urf Turabe, Chirumamilla, Chandra Sekhar, Perez-Novo, Claudina, Wong, Brandon Han Siang, Kumar, Sunil, Sze, Siu Kwan, Vanden Berghe, Wim, Verma, Navin Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637146/
https://www.ncbi.nlm.nih.gov/pubmed/34742736
http://dx.doi.org/10.1016/j.jbc.2021.101377

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637146/
https://www.ncbi.nlm.nih.gov/pubmed/34742736
http://dx.doi.org/10.1016/j.jbc.2021.101377

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