Cargando…

Hit Discovery for Public Target Programs in the European Lead Factory: Experiences and Output from Assay Development and Ultra-High-Throughput Screening

The European Lead Factory (ELF) consortium provides European academics and small and medium enterprises access to ~0.5 million unique compounds, a state-of-the-art ultra-high-throughput screening (u-HTS) platform, and industrial early drug discovery (DD) expertise with the aim of delivering innovati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Honarnejad, Saman, van Boeckel, Stan, van den Hurk, Helma, van Helden, Steven
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2020
Materias:	Perspective
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637381/ https://www.ncbi.nlm.nih.gov/pubmed/32734803 http://dx.doi.org/10.1177/2472555220942765

Ejemplares similares

Ultra-high-throughput Ca(2+) assay in platelets to distinguish ITAM-linked and G-protein-coupled receptor activation
por: Fernández, Delia I., et al.
Publicado: (2021)

Using Microscale Thermophoresis to Characterize Hits from High-Throughput Screening: A European Lead Factory Perspective
por: Rainard, Julie M., et al.
Publicado: (2018)

Advances in Ultrahigh Throughput Hit Discovery with Tandem Mass Spectrometry Encoded Libraries
por: Mata, J. Miguel, et al.
Publicado: (2023)

CERN bringer of the apocalypse or hit factory?
Publicado: (2008)

Surveillance perspective on Lyme borreliosis across the European Union and European Economic Area
por: van den Wijngaard, Cees C, et al.
Publicado: (2017)

Eye: The Hard-hit Victim of COVID-19 Pandemic
por: Gaur, Aman, et al.
Publicado: (2022)

Cell-based high-throughput screens for the discovery of chemotherapeutic agents
por: Fox, Jennifer T., et al.
Publicado: (2012)

Deep learning-based high-throughput phenotyping can drive future discoveries in plant reproductive biology
por: Warman, Cedar, et al.
Publicado: (2021)

Engineering microbial consortia for controllable outputs
por: Lindemann, Stephen R, et al.
Publicado: (2016)

Women at medical conferences 2016 – still hitting their head at the glass ceiling
por: Amrein, Karin, et al.
Publicado: (2017)

PubChem BioAssay: A Decade’s Development toward Open High-Throughput Screening Data Sharing
por: Wang, Yanli, et al.
Publicado: (2017)

Development and Implementation of a High-Throughput Compound Screening Assay for Targeting Disrupted ER Calcium Homeostasis in Alzheimer's Disease
por: Honarnejad, Kamran, et al.
Publicado: (2013)

Outside‐In Systems Pharmacology Combines Innovative Computational Methods With High‐Throughput Whole Vertebrate Studies
por: Schulthess, Pascal, et al.
Publicado: (2018)

Envisioning health equity for American Indian/Alaska Natives: a unique HIT opportunity
por: Cullen, Theresa, et al.
Publicado: (2019)

Prevention of human rabies: a challenge for the European Union and the European Economic Area
por: Gossner, Céline M, et al.
Publicado: (2020)

The Standard Output: A Tool‐Agnostic Modeling Storage Format
por: Terranova, Nadia, et al.
Publicado: (2018)

Identifying components for programmatic latent tuberculosis infection control in the European Union
por: Sandgren, Andreas, et al.
Publicado: (2016)

Biosimilars entering the clinic without animal studies: A paradigm shift in the European Union
por: van Aerts, Leon AGJM, et al.
Publicado: (2014)

Novel SNP Discovery in African Buffalo, Syncerus caffer, Using High-Throughput Sequencing
por: le Roex, Nikki, et al.
Publicado: (2012)

Is serine racemase (SRR) a second hit target for LRRK2-G2019S induced Parkinson’s disease?
por: Nickels, Sarah Louise, et al.
Publicado: (2020)

Targeting Protein Neddylation to Inactivate Cullin-RING Ligases by Gossypol: A Lucky Hit or a New Start?
por: Yu, Qing, et al.
Publicado: (2021)

High‐throughput colorimetric assays optimized for detection of ketones and aldehydes produced by microbial cell factories
por: Kozaeva, Ekaterina, et al.
Publicado: (2022)

Why use pre-differentiated cells to address complex multi-factorial neurodegenerative diseases?
por: Kopyov, Alex, et al.
Publicado: (2020)

The European Lead Factory: A Blueprint for Public–Private Partnerships in Early Drug Discovery
por: Karawajczyk, Anna, et al.
Publicado: (2017)

High-throughput SNP discovery and assay development in common bean
por: Hyten, David L, et al.
Publicado: (2010)

Dorsal root ganglia: fibromyalgia pain factory?
por: Martínez-Lavín, Manuel
Publicado: (2021)

European A-research cost is hit
por: Simons, H P
Publicado: (1964)

The high-throughput production of membrane proteins
por: Birch, James, et al.
Publicado: (2021)

A “two-hit” (chemo)therapy to improve checkpoint inhibition in cancer
por: Falvo, Paolo, et al.
Publicado: (2021)

Enhanced Vascular Contractility Following Secondhand Smoke Exposure: A Pathological “Double-hit” to Critical Smooth Muscle Ion Channels
por: Klug, Nicholas R, et al.
Publicado: (2021)

Bloom syndrome: research and data priorities for the development of precision medicine as identified by some affected families
por: Campbell, Mary Beth, et al.
Publicado: (2018)

A Static-Cidal Assay for Trypanosoma brucei to Aid Hit Prioritisation for Progression into Drug Discovery Programmes
por: De Rycker, Manu, et al.
Publicado: (2012)

Application of Ultra-Wide Band Sensors in Mining
por: Wisiak, Katja, et al.
Publicado: (2022)

Ultra‐processed foods: Processing versus formulation
por: Levine, Allen S., et al.
Publicado: (2023)

Drug Discovery for Schistosomiasis: Hit and Lead Compounds Identified in a Library of Known Drugs by Medium-Throughput Phenotypic Screening
por: Abdulla, Maha-Hamadien, et al.
Publicado: (2009)

A machine learning model trained on a high-throughput antibacterial screen increases the hit rate of drug discovery
por: Rahman, A. S. M. Zisanur, et al.
Publicado: (2022)

The European Repository Landscape 2008: Inventory of Digital Repositories for Research Output
por: Van der Graaf, Maurits
Publicado: (2009)

“Hit‐and‐Run” leaves its mark: Catalyst transcription factors and chromatin modification
por: Varala, Kranthi, et al.
Publicado: (2015)

Discovery and optimisation studies of antimalarial phenotypic hits
por: Mital, Alka, et al.
Publicado: (2015)

Are European Blue Economy ambitions in conflict with European environmental visions?
por: Andersen, Jesper H., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_9nr819ecf13c7mmd433f8frinv