Cargando…

Biopsy Artifact in Laser Interstitial Thermal Therapy: A Technical Note

PURPOSE: The safety and effectiveness of laser interstitial thermal therapy (LITT) relies critically on the ability to continuously monitor the ablation based on real-time temperature mapping using magnetic resonance thermometry (MRT). This technique uses gradient recalled echo (GRE) sequences that...

Descripción completa

Detalles Bibliográficos
Autores principales: Noh, Thomas, Juvekar, Parikshit, Huang, Raymond, Lee, Gunnar, Ogasawara, Christian T., Golby, Alexandra J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637457/
https://www.ncbi.nlm.nih.gov/pubmed/34868945
http://dx.doi.org/10.3389/fonc.2021.746416
_version_ 1784608744824373248
author Noh, Thomas
Juvekar, Parikshit
Huang, Raymond
Lee, Gunnar
Ogasawara, Christian T.
Golby, Alexandra J.
author_facet Noh, Thomas
Juvekar, Parikshit
Huang, Raymond
Lee, Gunnar
Ogasawara, Christian T.
Golby, Alexandra J.
author_sort Noh, Thomas
collection PubMed
description PURPOSE: The safety and effectiveness of laser interstitial thermal therapy (LITT) relies critically on the ability to continuously monitor the ablation based on real-time temperature mapping using magnetic resonance thermometry (MRT). This technique uses gradient recalled echo (GRE) sequences that are especially sensitive to susceptibility effects from air and blood. LITT for brain tumors is often preceded by a biopsy and is anecdotally associated with artifact during ablation. Thus, we reviewed our experience and describe the qualitative signal dropout that can interfere with ablation. METHODS: We retrospectively reviewed all LITT cases performed in our intraoperative MRI suite for tumors between 2017 and 2020. We identified a total of 17 LITT cases. Cases were reviewed for age, sex, pathology, presence of artifact, operative technique, and presence of blood/air on post-operative scans. RESULTS: We identified six cases that were preceded by biopsy, all six had artifact present during ablation, and all six were noted to have air/blood on their post-operative MRI or CT scans. In two of those cases, the artifactual signal dropout qualitatively interfered with thermal damage thresholds at the borders of the tumor. There was no artifact in the 11 non-biopsy cases and no obvious blood or air was noted on the post-ablation scans. CONCLUSION: Additional consideration should be given to pre-LITT biopsies. The presence of air/blood caused an artifactual signal dropout effect in cases with biopsy that was severe enough to interfere with ablation in a significant number of those cases. Additional studies are needed to identify modifying strategies.
format Online
Article
Text
id pubmed-8637457
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-86374572021-12-03 Biopsy Artifact in Laser Interstitial Thermal Therapy: A Technical Note Noh, Thomas Juvekar, Parikshit Huang, Raymond Lee, Gunnar Ogasawara, Christian T. Golby, Alexandra J. Front Oncol Oncology PURPOSE: The safety and effectiveness of laser interstitial thermal therapy (LITT) relies critically on the ability to continuously monitor the ablation based on real-time temperature mapping using magnetic resonance thermometry (MRT). This technique uses gradient recalled echo (GRE) sequences that are especially sensitive to susceptibility effects from air and blood. LITT for brain tumors is often preceded by a biopsy and is anecdotally associated with artifact during ablation. Thus, we reviewed our experience and describe the qualitative signal dropout that can interfere with ablation. METHODS: We retrospectively reviewed all LITT cases performed in our intraoperative MRI suite for tumors between 2017 and 2020. We identified a total of 17 LITT cases. Cases were reviewed for age, sex, pathology, presence of artifact, operative technique, and presence of blood/air on post-operative scans. RESULTS: We identified six cases that were preceded by biopsy, all six had artifact present during ablation, and all six were noted to have air/blood on their post-operative MRI or CT scans. In two of those cases, the artifactual signal dropout qualitatively interfered with thermal damage thresholds at the borders of the tumor. There was no artifact in the 11 non-biopsy cases and no obvious blood or air was noted on the post-ablation scans. CONCLUSION: Additional consideration should be given to pre-LITT biopsies. The presence of air/blood caused an artifactual signal dropout effect in cases with biopsy that was severe enough to interfere with ablation in a significant number of those cases. Additional studies are needed to identify modifying strategies. Frontiers Media S.A. 2021-11-18 /pmc/articles/PMC8637457/ /pubmed/34868945 http://dx.doi.org/10.3389/fonc.2021.746416 Text en Copyright © 2021 Noh, Juvekar, Huang, Lee, Ogasawara and Golby https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Noh, Thomas
Juvekar, Parikshit
Huang, Raymond
Lee, Gunnar
Ogasawara, Christian T.
Golby, Alexandra J.
Biopsy Artifact in Laser Interstitial Thermal Therapy: A Technical Note
title Biopsy Artifact in Laser Interstitial Thermal Therapy: A Technical Note
title_full Biopsy Artifact in Laser Interstitial Thermal Therapy: A Technical Note
title_fullStr Biopsy Artifact in Laser Interstitial Thermal Therapy: A Technical Note
title_full_unstemmed Biopsy Artifact in Laser Interstitial Thermal Therapy: A Technical Note
title_short Biopsy Artifact in Laser Interstitial Thermal Therapy: A Technical Note
title_sort biopsy artifact in laser interstitial thermal therapy: a technical note
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637457/
https://www.ncbi.nlm.nih.gov/pubmed/34868945
http://dx.doi.org/10.3389/fonc.2021.746416
work_keys_str_mv AT nohthomas biopsyartifactinlaserinterstitialthermaltherapyatechnicalnote
AT juvekarparikshit biopsyartifactinlaserinterstitialthermaltherapyatechnicalnote
AT huangraymond biopsyartifactinlaserinterstitialthermaltherapyatechnicalnote
AT leegunnar biopsyartifactinlaserinterstitialthermaltherapyatechnicalnote
AT ogasawarachristiant biopsyartifactinlaserinterstitialthermaltherapyatechnicalnote
AT golbyalexandraj biopsyartifactinlaserinterstitialthermaltherapyatechnicalnote