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Case Report: Neutralization of Autoantibodies Targeting G-Protein-Coupled Receptors Improves Capillary Impairment and Fatigue Symptoms After COVID-19 Infection

Clinical features of Coronavirus disease 2019 (COVID-19) are caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Acute infection management is a substantial healthcare issue, and the development of long-Covid syndrome (LCS) is extremely challenging for patients and physicians. It...

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Autores principales: Hohberger, Bettina, Harrer, Thomas, Mardin, Christian, Kruse, Friedrich, Hoffmanns, Jakob, Rogge, Lennart, Heltmann, Felix, Moritz, Michael, Szewczykowski, Charlotte, Schottenhamml, Julia, Kräter, Martin, Bergua, Antonio, Zenkel, Matthias, Gießl, Andreas, Schlötzer-Schrehardt, Ursula, Lämmer, Robert, Herrmann, Martin, Haberland, Annekathrin, Göttel, Peter, Müller, Johannes, Wallukat, Gerd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637609/
https://www.ncbi.nlm.nih.gov/pubmed/34869451
http://dx.doi.org/10.3389/fmed.2021.754667
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author Hohberger, Bettina
Harrer, Thomas
Mardin, Christian
Kruse, Friedrich
Hoffmanns, Jakob
Rogge, Lennart
Heltmann, Felix
Moritz, Michael
Szewczykowski, Charlotte
Schottenhamml, Julia
Kräter, Martin
Bergua, Antonio
Zenkel, Matthias
Gießl, Andreas
Schlötzer-Schrehardt, Ursula
Lämmer, Robert
Herrmann, Martin
Haberland, Annekathrin
Göttel, Peter
Müller, Johannes
Wallukat, Gerd
author_facet Hohberger, Bettina
Harrer, Thomas
Mardin, Christian
Kruse, Friedrich
Hoffmanns, Jakob
Rogge, Lennart
Heltmann, Felix
Moritz, Michael
Szewczykowski, Charlotte
Schottenhamml, Julia
Kräter, Martin
Bergua, Antonio
Zenkel, Matthias
Gießl, Andreas
Schlötzer-Schrehardt, Ursula
Lämmer, Robert
Herrmann, Martin
Haberland, Annekathrin
Göttel, Peter
Müller, Johannes
Wallukat, Gerd
author_sort Hohberger, Bettina
collection PubMed
description Clinical features of Coronavirus disease 2019 (COVID-19) are caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Acute infection management is a substantial healthcare issue, and the development of long-Covid syndrome (LCS) is extremely challenging for patients and physicians. It is associated with a variety of characteristics as impaired capillary microcirculation, chronic fatigue syndrome (CFS), proinflammatory cytokines, and functional autoantibodies targeting G-protein-coupled receptors (GPCR-AAbs). Here, we present a case report of successful healing of LCS with BC 007 (Berlin Cures, Berlin, Germany), a DNA aptamer drug with a high affinity to GPCR-AAbs that neutralizes these AAbs. A patient with a documented history of glaucoma, recovered from mild COVID-19, but still suffered from CFS, loss of taste, and impaired capillary microcirculation in the macula and peripapillary region. He was positively tested for various targeting GPCR-AAbs. Within 48 h after a single BC 007 treatment, GPCR-AAbs were functionally inactivated and remained inactive during the observation period of 4 weeks. This observation was accompanied by constant improvement of the fatigue symptoms of the patient, taste, and retinal capillary microcirculation. Therefore, the removal of GPCR-AAb might ameliorate the characteristics of the LCD, such as capillary impairment, loss of taste, and CFS.
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spelling pubmed-86376092021-12-03 Case Report: Neutralization of Autoantibodies Targeting G-Protein-Coupled Receptors Improves Capillary Impairment and Fatigue Symptoms After COVID-19 Infection Hohberger, Bettina Harrer, Thomas Mardin, Christian Kruse, Friedrich Hoffmanns, Jakob Rogge, Lennart Heltmann, Felix Moritz, Michael Szewczykowski, Charlotte Schottenhamml, Julia Kräter, Martin Bergua, Antonio Zenkel, Matthias Gießl, Andreas Schlötzer-Schrehardt, Ursula Lämmer, Robert Herrmann, Martin Haberland, Annekathrin Göttel, Peter Müller, Johannes Wallukat, Gerd Front Med (Lausanne) Medicine Clinical features of Coronavirus disease 2019 (COVID-19) are caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Acute infection management is a substantial healthcare issue, and the development of long-Covid syndrome (LCS) is extremely challenging for patients and physicians. It is associated with a variety of characteristics as impaired capillary microcirculation, chronic fatigue syndrome (CFS), proinflammatory cytokines, and functional autoantibodies targeting G-protein-coupled receptors (GPCR-AAbs). Here, we present a case report of successful healing of LCS with BC 007 (Berlin Cures, Berlin, Germany), a DNA aptamer drug with a high affinity to GPCR-AAbs that neutralizes these AAbs. A patient with a documented history of glaucoma, recovered from mild COVID-19, but still suffered from CFS, loss of taste, and impaired capillary microcirculation in the macula and peripapillary region. He was positively tested for various targeting GPCR-AAbs. Within 48 h after a single BC 007 treatment, GPCR-AAbs were functionally inactivated and remained inactive during the observation period of 4 weeks. This observation was accompanied by constant improvement of the fatigue symptoms of the patient, taste, and retinal capillary microcirculation. Therefore, the removal of GPCR-AAb might ameliorate the characteristics of the LCD, such as capillary impairment, loss of taste, and CFS. Frontiers Media S.A. 2021-11-18 /pmc/articles/PMC8637609/ /pubmed/34869451 http://dx.doi.org/10.3389/fmed.2021.754667 Text en Copyright © 2021 Hohberger, Harrer, Mardin, Kruse, Hoffmanns, Rogge, Heltmann, Moritz, Szewczykowski, Schottenhamml, Kräter, Bergua, Zenkel, Gießl, Schlötzer-Schrehardt, Lämmer, Herrmann, Haberland, Göttel, Müller and Wallukat. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Hohberger, Bettina
Harrer, Thomas
Mardin, Christian
Kruse, Friedrich
Hoffmanns, Jakob
Rogge, Lennart
Heltmann, Felix
Moritz, Michael
Szewczykowski, Charlotte
Schottenhamml, Julia
Kräter, Martin
Bergua, Antonio
Zenkel, Matthias
Gießl, Andreas
Schlötzer-Schrehardt, Ursula
Lämmer, Robert
Herrmann, Martin
Haberland, Annekathrin
Göttel, Peter
Müller, Johannes
Wallukat, Gerd
Case Report: Neutralization of Autoantibodies Targeting G-Protein-Coupled Receptors Improves Capillary Impairment and Fatigue Symptoms After COVID-19 Infection
title Case Report: Neutralization of Autoantibodies Targeting G-Protein-Coupled Receptors Improves Capillary Impairment and Fatigue Symptoms After COVID-19 Infection
title_full Case Report: Neutralization of Autoantibodies Targeting G-Protein-Coupled Receptors Improves Capillary Impairment and Fatigue Symptoms After COVID-19 Infection
title_fullStr Case Report: Neutralization of Autoantibodies Targeting G-Protein-Coupled Receptors Improves Capillary Impairment and Fatigue Symptoms After COVID-19 Infection
title_full_unstemmed Case Report: Neutralization of Autoantibodies Targeting G-Protein-Coupled Receptors Improves Capillary Impairment and Fatigue Symptoms After COVID-19 Infection
title_short Case Report: Neutralization of Autoantibodies Targeting G-Protein-Coupled Receptors Improves Capillary Impairment and Fatigue Symptoms After COVID-19 Infection
title_sort case report: neutralization of autoantibodies targeting g-protein-coupled receptors improves capillary impairment and fatigue symptoms after covid-19 infection
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637609/
https://www.ncbi.nlm.nih.gov/pubmed/34869451
http://dx.doi.org/10.3389/fmed.2021.754667
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