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Case Report: Neutralization of Autoantibodies Targeting G-Protein-Coupled Receptors Improves Capillary Impairment and Fatigue Symptoms After COVID-19 Infection
Clinical features of Coronavirus disease 2019 (COVID-19) are caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Acute infection management is a substantial healthcare issue, and the development of long-Covid syndrome (LCS) is extremely challenging for patients and physicians. It...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637609/ https://www.ncbi.nlm.nih.gov/pubmed/34869451 http://dx.doi.org/10.3389/fmed.2021.754667 |
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author | Hohberger, Bettina Harrer, Thomas Mardin, Christian Kruse, Friedrich Hoffmanns, Jakob Rogge, Lennart Heltmann, Felix Moritz, Michael Szewczykowski, Charlotte Schottenhamml, Julia Kräter, Martin Bergua, Antonio Zenkel, Matthias Gießl, Andreas Schlötzer-Schrehardt, Ursula Lämmer, Robert Herrmann, Martin Haberland, Annekathrin Göttel, Peter Müller, Johannes Wallukat, Gerd |
author_facet | Hohberger, Bettina Harrer, Thomas Mardin, Christian Kruse, Friedrich Hoffmanns, Jakob Rogge, Lennart Heltmann, Felix Moritz, Michael Szewczykowski, Charlotte Schottenhamml, Julia Kräter, Martin Bergua, Antonio Zenkel, Matthias Gießl, Andreas Schlötzer-Schrehardt, Ursula Lämmer, Robert Herrmann, Martin Haberland, Annekathrin Göttel, Peter Müller, Johannes Wallukat, Gerd |
author_sort | Hohberger, Bettina |
collection | PubMed |
description | Clinical features of Coronavirus disease 2019 (COVID-19) are caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Acute infection management is a substantial healthcare issue, and the development of long-Covid syndrome (LCS) is extremely challenging for patients and physicians. It is associated with a variety of characteristics as impaired capillary microcirculation, chronic fatigue syndrome (CFS), proinflammatory cytokines, and functional autoantibodies targeting G-protein-coupled receptors (GPCR-AAbs). Here, we present a case report of successful healing of LCS with BC 007 (Berlin Cures, Berlin, Germany), a DNA aptamer drug with a high affinity to GPCR-AAbs that neutralizes these AAbs. A patient with a documented history of glaucoma, recovered from mild COVID-19, but still suffered from CFS, loss of taste, and impaired capillary microcirculation in the macula and peripapillary region. He was positively tested for various targeting GPCR-AAbs. Within 48 h after a single BC 007 treatment, GPCR-AAbs were functionally inactivated and remained inactive during the observation period of 4 weeks. This observation was accompanied by constant improvement of the fatigue symptoms of the patient, taste, and retinal capillary microcirculation. Therefore, the removal of GPCR-AAb might ameliorate the characteristics of the LCD, such as capillary impairment, loss of taste, and CFS. |
format | Online Article Text |
id | pubmed-8637609 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86376092021-12-03 Case Report: Neutralization of Autoantibodies Targeting G-Protein-Coupled Receptors Improves Capillary Impairment and Fatigue Symptoms After COVID-19 Infection Hohberger, Bettina Harrer, Thomas Mardin, Christian Kruse, Friedrich Hoffmanns, Jakob Rogge, Lennart Heltmann, Felix Moritz, Michael Szewczykowski, Charlotte Schottenhamml, Julia Kräter, Martin Bergua, Antonio Zenkel, Matthias Gießl, Andreas Schlötzer-Schrehardt, Ursula Lämmer, Robert Herrmann, Martin Haberland, Annekathrin Göttel, Peter Müller, Johannes Wallukat, Gerd Front Med (Lausanne) Medicine Clinical features of Coronavirus disease 2019 (COVID-19) are caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Acute infection management is a substantial healthcare issue, and the development of long-Covid syndrome (LCS) is extremely challenging for patients and physicians. It is associated with a variety of characteristics as impaired capillary microcirculation, chronic fatigue syndrome (CFS), proinflammatory cytokines, and functional autoantibodies targeting G-protein-coupled receptors (GPCR-AAbs). Here, we present a case report of successful healing of LCS with BC 007 (Berlin Cures, Berlin, Germany), a DNA aptamer drug with a high affinity to GPCR-AAbs that neutralizes these AAbs. A patient with a documented history of glaucoma, recovered from mild COVID-19, but still suffered from CFS, loss of taste, and impaired capillary microcirculation in the macula and peripapillary region. He was positively tested for various targeting GPCR-AAbs. Within 48 h after a single BC 007 treatment, GPCR-AAbs were functionally inactivated and remained inactive during the observation period of 4 weeks. This observation was accompanied by constant improvement of the fatigue symptoms of the patient, taste, and retinal capillary microcirculation. Therefore, the removal of GPCR-AAb might ameliorate the characteristics of the LCD, such as capillary impairment, loss of taste, and CFS. Frontiers Media S.A. 2021-11-18 /pmc/articles/PMC8637609/ /pubmed/34869451 http://dx.doi.org/10.3389/fmed.2021.754667 Text en Copyright © 2021 Hohberger, Harrer, Mardin, Kruse, Hoffmanns, Rogge, Heltmann, Moritz, Szewczykowski, Schottenhamml, Kräter, Bergua, Zenkel, Gießl, Schlötzer-Schrehardt, Lämmer, Herrmann, Haberland, Göttel, Müller and Wallukat. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Hohberger, Bettina Harrer, Thomas Mardin, Christian Kruse, Friedrich Hoffmanns, Jakob Rogge, Lennart Heltmann, Felix Moritz, Michael Szewczykowski, Charlotte Schottenhamml, Julia Kräter, Martin Bergua, Antonio Zenkel, Matthias Gießl, Andreas Schlötzer-Schrehardt, Ursula Lämmer, Robert Herrmann, Martin Haberland, Annekathrin Göttel, Peter Müller, Johannes Wallukat, Gerd Case Report: Neutralization of Autoantibodies Targeting G-Protein-Coupled Receptors Improves Capillary Impairment and Fatigue Symptoms After COVID-19 Infection |
title | Case Report: Neutralization of Autoantibodies Targeting G-Protein-Coupled Receptors Improves Capillary Impairment and Fatigue Symptoms After COVID-19 Infection |
title_full | Case Report: Neutralization of Autoantibodies Targeting G-Protein-Coupled Receptors Improves Capillary Impairment and Fatigue Symptoms After COVID-19 Infection |
title_fullStr | Case Report: Neutralization of Autoantibodies Targeting G-Protein-Coupled Receptors Improves Capillary Impairment and Fatigue Symptoms After COVID-19 Infection |
title_full_unstemmed | Case Report: Neutralization of Autoantibodies Targeting G-Protein-Coupled Receptors Improves Capillary Impairment and Fatigue Symptoms After COVID-19 Infection |
title_short | Case Report: Neutralization of Autoantibodies Targeting G-Protein-Coupled Receptors Improves Capillary Impairment and Fatigue Symptoms After COVID-19 Infection |
title_sort | case report: neutralization of autoantibodies targeting g-protein-coupled receptors improves capillary impairment and fatigue symptoms after covid-19 infection |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637609/ https://www.ncbi.nlm.nih.gov/pubmed/34869451 http://dx.doi.org/10.3389/fmed.2021.754667 |
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