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Epigenetic Priming of Bladder Cancer Cells With Decitabine Increases Cytotoxicity of Human EGFR and CD44v6 CAR Engineered T-Cells

BACKGROUND: Treatment of B-cell malignancies with CD19-directed chimeric antigen receptor (CAR) T-cells marked a new era in immunotherapy, which yet has to be successfully adopted to solid cancers. Epigenetic inhibitors of DNA methyltransferases (DNMTi) and histone deacetylases (HDACi) can induce br...

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Detalles Bibliográficos
Autores principales:	Grunewald, Camilla M., Haist, Corinna, König, Carolin, Petzsch, Patrick, Bister, Arthur, Nößner, Elfriede, Wiek, Constanze, Scheckenbach, Kathrin, Köhrer, Karl, Niegisch, Günter, Hanenberg, Helmut, Hoffmann, Michèle J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637820/ https://www.ncbi.nlm.nih.gov/pubmed/34868059 http://dx.doi.org/10.3389/fimmu.2021.782448

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