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Distinct Patterns of P1 and C2 VEP Potentiation and Attenuation in Visual Snow: A Case Report

Visual snow syndrome, characterized by persistent flickering dots throughout the visual field, has been hypothesized to arise from abnormal neuronal responsiveness in visual processing regions. Previous research has reported a lack of typical VEP habituation to repeated stimulus presentation in pati...

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Autor principal: Harris, Alison M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637848/
https://www.ncbi.nlm.nih.gov/pubmed/34867714
http://dx.doi.org/10.3389/fneur.2021.723677
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author Harris, Alison M.
author_facet Harris, Alison M.
author_sort Harris, Alison M.
collection PubMed
description Visual snow syndrome, characterized by persistent flickering dots throughout the visual field, has been hypothesized to arise from abnormal neuronal responsiveness in visual processing regions. Previous research has reported a lack of typical VEP habituation to repeated stimulus presentation in patients with visual snow. Yet these studies generally used pattern-reversal paradigms, which are suboptimal for measuring cortical responses to the onset of foveal stimulation. Instead, these responses are better indexed by the C2, a pattern-onset VEP peaking 100–120 ms after stimulus onset. In this case study, we analyzed the C2 and its adaptation profile in data previously collected from a single patient with visual snow using a “double-pulse” presentation paradigm. In controls, shorter intervals between stimulus pairs were associated with greater attenuation of the C2 VEP, with recovery from adaptation at longer stimulus onset asynchronies (SOAs). However, the visual snow patient showed the opposite pattern, with reduced C2 amplitude at longer SOAs despite distinct C2 peaks at the shortest SOAs. These results stand in contrast not only to the pattern of C2 VEP attenuation in controls, but also to a lack of adaptation previously reported for the pattern-onset P1 VEP in this patient. Exploratory source localization using equivalent current dipole fitting further suggested that P1 and C2 VEPs in the visual snow patient arose from distinct sources in extrastriate visual cortex. While preliminary, these results support differential patterns of VEP attenuation and potentiation within the same individual, potentially pointing toward multiple mechanisms of abnormal neuronal responsiveness in visual snow syndrome.
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spelling pubmed-86378482021-12-03 Distinct Patterns of P1 and C2 VEP Potentiation and Attenuation in Visual Snow: A Case Report Harris, Alison M. Front Neurol Neurology Visual snow syndrome, characterized by persistent flickering dots throughout the visual field, has been hypothesized to arise from abnormal neuronal responsiveness in visual processing regions. Previous research has reported a lack of typical VEP habituation to repeated stimulus presentation in patients with visual snow. Yet these studies generally used pattern-reversal paradigms, which are suboptimal for measuring cortical responses to the onset of foveal stimulation. Instead, these responses are better indexed by the C2, a pattern-onset VEP peaking 100–120 ms after stimulus onset. In this case study, we analyzed the C2 and its adaptation profile in data previously collected from a single patient with visual snow using a “double-pulse” presentation paradigm. In controls, shorter intervals between stimulus pairs were associated with greater attenuation of the C2 VEP, with recovery from adaptation at longer stimulus onset asynchronies (SOAs). However, the visual snow patient showed the opposite pattern, with reduced C2 amplitude at longer SOAs despite distinct C2 peaks at the shortest SOAs. These results stand in contrast not only to the pattern of C2 VEP attenuation in controls, but also to a lack of adaptation previously reported for the pattern-onset P1 VEP in this patient. Exploratory source localization using equivalent current dipole fitting further suggested that P1 and C2 VEPs in the visual snow patient arose from distinct sources in extrastriate visual cortex. While preliminary, these results support differential patterns of VEP attenuation and potentiation within the same individual, potentially pointing toward multiple mechanisms of abnormal neuronal responsiveness in visual snow syndrome. Frontiers Media S.A. 2021-11-17 /pmc/articles/PMC8637848/ /pubmed/34867714 http://dx.doi.org/10.3389/fneur.2021.723677 Text en Copyright © 2021 Harris. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Harris, Alison M.
Distinct Patterns of P1 and C2 VEP Potentiation and Attenuation in Visual Snow: A Case Report
title Distinct Patterns of P1 and C2 VEP Potentiation and Attenuation in Visual Snow: A Case Report
title_full Distinct Patterns of P1 and C2 VEP Potentiation and Attenuation in Visual Snow: A Case Report
title_fullStr Distinct Patterns of P1 and C2 VEP Potentiation and Attenuation in Visual Snow: A Case Report
title_full_unstemmed Distinct Patterns of P1 and C2 VEP Potentiation and Attenuation in Visual Snow: A Case Report
title_short Distinct Patterns of P1 and C2 VEP Potentiation and Attenuation in Visual Snow: A Case Report
title_sort distinct patterns of p1 and c2 vep potentiation and attenuation in visual snow: a case report
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637848/
https://www.ncbi.nlm.nih.gov/pubmed/34867714
http://dx.doi.org/10.3389/fneur.2021.723677
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