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HOTAIR Modulated Pathways in Early-Stage Breast Cancer Progression

The long-non-coding HOX transcript antisense intergenic RNA (HOTAIR) was identified as significantly upregulated in breast ductal carcinoma in situ (DCIS). The aim of this study was to characterize the phenotypic effects and signaling pathways modulated by HOTAIR in early-stage breast cancer progres...

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Autores principales: Abba, Martin C., Fabre, María Laura, Lee, Jaeho, Tatineni, Pradeep, Kil, Hyunsuk, Aldaz, C. Marcelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637884/
https://www.ncbi.nlm.nih.gov/pubmed/34869037
http://dx.doi.org/10.3389/fonc.2021.783211
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author Abba, Martin C.
Fabre, María Laura
Lee, Jaeho
Tatineni, Pradeep
Kil, Hyunsuk
Aldaz, C. Marcelo
author_facet Abba, Martin C.
Fabre, María Laura
Lee, Jaeho
Tatineni, Pradeep
Kil, Hyunsuk
Aldaz, C. Marcelo
author_sort Abba, Martin C.
collection PubMed
description The long-non-coding HOX transcript antisense intergenic RNA (HOTAIR) was identified as significantly upregulated in breast ductal carcinoma in situ (DCIS). The aim of this study was to characterize the phenotypic effects and signaling pathways modulated by HOTAIR in early-stage breast cancer progression. We determined that HOTAIR induces premalignant phenotypic changes by increasing cell proliferation, migration, invasion and in vivo growth in normal and DCIS breast cell lines. Transcriptomic studies (RNA-seq) identified the main signaling pathways modulated by HOTAIR which include bioprocesses related to epithelial to mesenchymal transition, cell migration, extracellular matrix remodeling and activation of several signaling pathways (HIF1A, AP1 and FGFR). Similar pathways were identified as activated in primary invasive breast carcinomas with HOTAIR over-expression. We conclude that HOTAIR over-expression behaves as a positive regulator of cell growth and migration both in normal and DCIS breast cells involved with early-stage breast cancer progression.
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spelling pubmed-86378842021-12-03 HOTAIR Modulated Pathways in Early-Stage Breast Cancer Progression Abba, Martin C. Fabre, María Laura Lee, Jaeho Tatineni, Pradeep Kil, Hyunsuk Aldaz, C. Marcelo Front Oncol Oncology The long-non-coding HOX transcript antisense intergenic RNA (HOTAIR) was identified as significantly upregulated in breast ductal carcinoma in situ (DCIS). The aim of this study was to characterize the phenotypic effects and signaling pathways modulated by HOTAIR in early-stage breast cancer progression. We determined that HOTAIR induces premalignant phenotypic changes by increasing cell proliferation, migration, invasion and in vivo growth in normal and DCIS breast cell lines. Transcriptomic studies (RNA-seq) identified the main signaling pathways modulated by HOTAIR which include bioprocesses related to epithelial to mesenchymal transition, cell migration, extracellular matrix remodeling and activation of several signaling pathways (HIF1A, AP1 and FGFR). Similar pathways were identified as activated in primary invasive breast carcinomas with HOTAIR over-expression. We conclude that HOTAIR over-expression behaves as a positive regulator of cell growth and migration both in normal and DCIS breast cells involved with early-stage breast cancer progression. Frontiers Media S.A. 2021-11-17 /pmc/articles/PMC8637884/ /pubmed/34869037 http://dx.doi.org/10.3389/fonc.2021.783211 Text en Copyright © 2021 Abba, Fabre, Lee, Tatineni, Kil and Aldaz https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Abba, Martin C.
Fabre, María Laura
Lee, Jaeho
Tatineni, Pradeep
Kil, Hyunsuk
Aldaz, C. Marcelo
HOTAIR Modulated Pathways in Early-Stage Breast Cancer Progression
title HOTAIR Modulated Pathways in Early-Stage Breast Cancer Progression
title_full HOTAIR Modulated Pathways in Early-Stage Breast Cancer Progression
title_fullStr HOTAIR Modulated Pathways in Early-Stage Breast Cancer Progression
title_full_unstemmed HOTAIR Modulated Pathways in Early-Stage Breast Cancer Progression
title_short HOTAIR Modulated Pathways in Early-Stage Breast Cancer Progression
title_sort hotair modulated pathways in early-stage breast cancer progression
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637884/
https://www.ncbi.nlm.nih.gov/pubmed/34869037
http://dx.doi.org/10.3389/fonc.2021.783211
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