Emerging Roles of Pleckstrin-2 Beyond Cell Spreading

Pleckstrin-2 is a member of pleckstrin family with well-defined structural features that was first identified in 1999. Over the past 20 years, our understanding of PLEK2 biology has been limited to cell spreading. Recently, increasing evidences support that PLEK2 plays important roles in other cellu...

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Autores principales: Wang, Gengchen, Zhou, Qian, Xu, Yan, Zhao, Baobing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637889/
https://www.ncbi.nlm.nih.gov/pubmed/34869363
http://dx.doi.org/10.3389/fcell.2021.768238
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author Wang, Gengchen
Zhou, Qian
Xu, Yan
Zhao, Baobing
author_facet Wang, Gengchen
Zhou, Qian
Xu, Yan
Zhao, Baobing
author_sort Wang, Gengchen
collection PubMed
description Pleckstrin-2 is a member of pleckstrin family with well-defined structural features that was first identified in 1999. Over the past 20 years, our understanding of PLEK2 biology has been limited to cell spreading. Recently, increasing evidences support that PLEK2 plays important roles in other cellular events beyond cell spreading, such as erythropoiesis, tumorigenesis and metastasis. It serves as a potential diagnostic and prognostic biomarker as well as an attractive target for the treatment of cancers. Herein, we summary the protein structure and molecular interactions of pleckstrin-2, with an emphasis on its regulatory roles in tumorigenesis.
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spelling pubmed-86378892021-12-03 Emerging Roles of Pleckstrin-2 Beyond Cell Spreading Wang, Gengchen Zhou, Qian Xu, Yan Zhao, Baobing Front Cell Dev Biol Cell and Developmental Biology Pleckstrin-2 is a member of pleckstrin family with well-defined structural features that was first identified in 1999. Over the past 20 years, our understanding of PLEK2 biology has been limited to cell spreading. Recently, increasing evidences support that PLEK2 plays important roles in other cellular events beyond cell spreading, such as erythropoiesis, tumorigenesis and metastasis. It serves as a potential diagnostic and prognostic biomarker as well as an attractive target for the treatment of cancers. Herein, we summary the protein structure and molecular interactions of pleckstrin-2, with an emphasis on its regulatory roles in tumorigenesis. Frontiers Media S.A. 2021-11-17 /pmc/articles/PMC8637889/ /pubmed/34869363 http://dx.doi.org/10.3389/fcell.2021.768238 Text en Copyright © 2021 Wang, Zhou, Xu and Zhao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Wang, Gengchen
Zhou, Qian
Xu, Yan
Zhao, Baobing
Emerging Roles of Pleckstrin-2 Beyond Cell Spreading
title Emerging Roles of Pleckstrin-2 Beyond Cell Spreading
title_full Emerging Roles of Pleckstrin-2 Beyond Cell Spreading
title_fullStr Emerging Roles of Pleckstrin-2 Beyond Cell Spreading
title_full_unstemmed Emerging Roles of Pleckstrin-2 Beyond Cell Spreading
title_short Emerging Roles of Pleckstrin-2 Beyond Cell Spreading
title_sort emerging roles of pleckstrin-2 beyond cell spreading
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637889/
https://www.ncbi.nlm.nih.gov/pubmed/34869363
http://dx.doi.org/10.3389/fcell.2021.768238
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