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Increased ApoE Expression in Follicular Fluid and the ApoE Genotype Are Associated With Endometriosis in Chinese Women

More than 10% of women suffer from endometriosis (EMT) during their reproductive years. EMT can cause pain and infertility and requires further study from multiple perspectives. Previous reports have indicated that an increase inapolipoprotein E (ApoE) may be associated with a lower number of retrie...

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Autores principales: Liu, Ya-Jing, Xing, Fen, Zong, Kai, Wang, Meng-Yao, Ji, Dong-Mei, Zhao, Yu-Hang, Xia, Yun-He, Wang, An, Shi, Ling-Ge, Ding, Si-Min, Wei, Zhao-Lian, Qiao, Jin-Ping, Du, Xin, Cao, Yun-Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8638081/
https://www.ncbi.nlm.nih.gov/pubmed/34867826
http://dx.doi.org/10.3389/fendo.2021.779183
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author Liu, Ya-Jing
Xing, Fen
Zong, Kai
Wang, Meng-Yao
Ji, Dong-Mei
Zhao, Yu-Hang
Xia, Yun-He
Wang, An
Shi, Ling-Ge
Ding, Si-Min
Wei, Zhao-Lian
Qiao, Jin-Ping
Du, Xin
Cao, Yun-Xia
author_facet Liu, Ya-Jing
Xing, Fen
Zong, Kai
Wang, Meng-Yao
Ji, Dong-Mei
Zhao, Yu-Hang
Xia, Yun-He
Wang, An
Shi, Ling-Ge
Ding, Si-Min
Wei, Zhao-Lian
Qiao, Jin-Ping
Du, Xin
Cao, Yun-Xia
author_sort Liu, Ya-Jing
collection PubMed
description More than 10% of women suffer from endometriosis (EMT) during their reproductive years. EMT can cause pain and infertility and requires further study from multiple perspectives. Previous reports have indicated that an increase inapolipoprotein E (ApoE) may be associated with a lower number of retrieved mature oocytes in older women, and an association between ApoE and spontaneous pregnancy loss may exist in patients with EMT. The purpose of this study was to investigate the existence of an increase in ApoE in follicular fluid (FF) and the possible relationship between ApoE and EMT in Chinese women. In the current study, 217 Chinese women (111 control subjects and 106 EMT patients) were included. The ApoE genotypes were identified by Sanger sequencing. We found that ApoE expression in FF was higher in patients with EMT than in the control group. In addition, a significant difference in ApoE4 carriers (ϵ3/ϵ4, ϵ4/ϵ4) was found between the control subjects and the patients with EMT. Furthermore, a nonparametric test revealed significant differences in the numbers of blastocysts and high-quality blastocysts, but not the hormone levels of FSH, LH, and E2, between the two groups. We also established a multifactor (BMI, high-quality blastocysts, and ϵ4) prediction model with good sensitivity for identifying patients who may suffer from EMT. Our results demonstrate that ApoE expression in FF is increased in EMT, the ApoE-ϵ4 allele is significantly linked to EMT, and a combined analysis of three factors (BMI, high-quality blastocysts, and ϵ4) could be used as a predictor of EMT.
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spelling pubmed-86380812021-12-03 Increased ApoE Expression in Follicular Fluid and the ApoE Genotype Are Associated With Endometriosis in Chinese Women Liu, Ya-Jing Xing, Fen Zong, Kai Wang, Meng-Yao Ji, Dong-Mei Zhao, Yu-Hang Xia, Yun-He Wang, An Shi, Ling-Ge Ding, Si-Min Wei, Zhao-Lian Qiao, Jin-Ping Du, Xin Cao, Yun-Xia Front Endocrinol (Lausanne) Endocrinology More than 10% of women suffer from endometriosis (EMT) during their reproductive years. EMT can cause pain and infertility and requires further study from multiple perspectives. Previous reports have indicated that an increase inapolipoprotein E (ApoE) may be associated with a lower number of retrieved mature oocytes in older women, and an association between ApoE and spontaneous pregnancy loss may exist in patients with EMT. The purpose of this study was to investigate the existence of an increase in ApoE in follicular fluid (FF) and the possible relationship between ApoE and EMT in Chinese women. In the current study, 217 Chinese women (111 control subjects and 106 EMT patients) were included. The ApoE genotypes were identified by Sanger sequencing. We found that ApoE expression in FF was higher in patients with EMT than in the control group. In addition, a significant difference in ApoE4 carriers (ϵ3/ϵ4, ϵ4/ϵ4) was found between the control subjects and the patients with EMT. Furthermore, a nonparametric test revealed significant differences in the numbers of blastocysts and high-quality blastocysts, but not the hormone levels of FSH, LH, and E2, between the two groups. We also established a multifactor (BMI, high-quality blastocysts, and ϵ4) prediction model with good sensitivity for identifying patients who may suffer from EMT. Our results demonstrate that ApoE expression in FF is increased in EMT, the ApoE-ϵ4 allele is significantly linked to EMT, and a combined analysis of three factors (BMI, high-quality blastocysts, and ϵ4) could be used as a predictor of EMT. Frontiers Media S.A. 2021-11-10 /pmc/articles/PMC8638081/ /pubmed/34867826 http://dx.doi.org/10.3389/fendo.2021.779183 Text en Copyright © 2021 Liu, Xing, Zong, Wang, Ji, Zhao, Xia, Wang, Shi, Ding, Wei, Qiao, Du and Cao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Liu, Ya-Jing
Xing, Fen
Zong, Kai
Wang, Meng-Yao
Ji, Dong-Mei
Zhao, Yu-Hang
Xia, Yun-He
Wang, An
Shi, Ling-Ge
Ding, Si-Min
Wei, Zhao-Lian
Qiao, Jin-Ping
Du, Xin
Cao, Yun-Xia
Increased ApoE Expression in Follicular Fluid and the ApoE Genotype Are Associated With Endometriosis in Chinese Women
title Increased ApoE Expression in Follicular Fluid and the ApoE Genotype Are Associated With Endometriosis in Chinese Women
title_full Increased ApoE Expression in Follicular Fluid and the ApoE Genotype Are Associated With Endometriosis in Chinese Women
title_fullStr Increased ApoE Expression in Follicular Fluid and the ApoE Genotype Are Associated With Endometriosis in Chinese Women
title_full_unstemmed Increased ApoE Expression in Follicular Fluid and the ApoE Genotype Are Associated With Endometriosis in Chinese Women
title_short Increased ApoE Expression in Follicular Fluid and the ApoE Genotype Are Associated With Endometriosis in Chinese Women
title_sort increased apoe expression in follicular fluid and the apoe genotype are associated with endometriosis in chinese women
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8638081/
https://www.ncbi.nlm.nih.gov/pubmed/34867826
http://dx.doi.org/10.3389/fendo.2021.779183
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