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The Relationship Between Osteoporosis and Intestinal Microbes in the Henan Province of China

Osteoporosis (OP) is a chronic disease in the elderly, and China is entering an aging demographic trend. In recent years, increasing evidence has demonstrated that probiotics can treat osteoporosis. This study aimed to explore the relevant mechanisms and to validate the beneficial effect on osteopor...

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Autores principales: Qin, Qian, Yan, Su, Yang, Yang, Chen, Jingfeng, Yan, Hang, Li, Tiantian, Gao, Xinxin, Wang, Youxiang, Li, Ang, Wang, Shoujun, Ding, Suying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8638085/
https://www.ncbi.nlm.nih.gov/pubmed/34869341
http://dx.doi.org/10.3389/fcell.2021.752990
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author Qin, Qian
Yan, Su
Yang, Yang
Chen, Jingfeng
Yan, Hang
Li, Tiantian
Gao, Xinxin
Wang, Youxiang
Li, Ang
Wang, Shoujun
Ding, Suying
author_facet Qin, Qian
Yan, Su
Yang, Yang
Chen, Jingfeng
Yan, Hang
Li, Tiantian
Gao, Xinxin
Wang, Youxiang
Li, Ang
Wang, Shoujun
Ding, Suying
author_sort Qin, Qian
collection PubMed
description Osteoporosis (OP) is a chronic disease in the elderly, and China is entering an aging demographic trend. In recent years, increasing evidence has demonstrated that probiotics can treat osteoporosis. This study aimed to explore the relevant mechanisms and to validate the beneficial effect on osteoporosis by high-throughput metagenome-wide gene sequencing in humans. In this study, compared with controls, several species had altered abundances, and specific functional pathways were found in the OP group. At the species level, the species that had increased in OP individuals were positively correlated to bone resorption markers and negatively correlated to 25-OH-D3 and bone formation markers, with Streptococcus sanguinis showing the strongest relevance, followed by Streptococcus gordonii, Actinomyces odontolyticus, and Olsenella unclassified. Additionally, Actinomyces graevenitzii, enriched in the OP group, was positively correlated to inflammation indicators that included white blood cell (WBC), neutrophil count (NEC), and the neutrophil-to-lymphocyte ratio (NLR) (p < 0.05). Conversely, the levels of Akkermansia muciniphila, Bacteroides eggerthii, Bacteroides fragilis, Bacteroides uniformis, and Butyricimonas synergistic were increased in the control group, which had a negative correlation with bone resorption markers and positive correlation with bone formation markers and 25-OH-D3. Additionally, Bacteroides fragilis had a negative correlation with inflammation indicators (WBC, NEC, and NLR) and the above pathways (p < 0.05). Functional prediction revealed that 106 metabolic pathways, enriched in the OP group, were significantly higher than in the control group (p < 0.05). In particular, pathways related to LPS biosynthesis, phytate degradation, lactate acid, and ethanol fermentation were more abundant in the OP group than in the control and were positively related to WBC and NEC. Taken together, several species with altered abundances and specific functional pathways were found in OP individuals. The role of phytases in OP provides novel epidemiological evidence to elucidate the underlying microbiota-relevant mechanisms in bone mineralization and should be explored further.
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spelling pubmed-86380852021-12-03 The Relationship Between Osteoporosis and Intestinal Microbes in the Henan Province of China Qin, Qian Yan, Su Yang, Yang Chen, Jingfeng Yan, Hang Li, Tiantian Gao, Xinxin Wang, Youxiang Li, Ang Wang, Shoujun Ding, Suying Front Cell Dev Biol Cell and Developmental Biology Osteoporosis (OP) is a chronic disease in the elderly, and China is entering an aging demographic trend. In recent years, increasing evidence has demonstrated that probiotics can treat osteoporosis. This study aimed to explore the relevant mechanisms and to validate the beneficial effect on osteoporosis by high-throughput metagenome-wide gene sequencing in humans. In this study, compared with controls, several species had altered abundances, and specific functional pathways were found in the OP group. At the species level, the species that had increased in OP individuals were positively correlated to bone resorption markers and negatively correlated to 25-OH-D3 and bone formation markers, with Streptococcus sanguinis showing the strongest relevance, followed by Streptococcus gordonii, Actinomyces odontolyticus, and Olsenella unclassified. Additionally, Actinomyces graevenitzii, enriched in the OP group, was positively correlated to inflammation indicators that included white blood cell (WBC), neutrophil count (NEC), and the neutrophil-to-lymphocyte ratio (NLR) (p < 0.05). Conversely, the levels of Akkermansia muciniphila, Bacteroides eggerthii, Bacteroides fragilis, Bacteroides uniformis, and Butyricimonas synergistic were increased in the control group, which had a negative correlation with bone resorption markers and positive correlation with bone formation markers and 25-OH-D3. Additionally, Bacteroides fragilis had a negative correlation with inflammation indicators (WBC, NEC, and NLR) and the above pathways (p < 0.05). Functional prediction revealed that 106 metabolic pathways, enriched in the OP group, were significantly higher than in the control group (p < 0.05). In particular, pathways related to LPS biosynthesis, phytate degradation, lactate acid, and ethanol fermentation were more abundant in the OP group than in the control and were positively related to WBC and NEC. Taken together, several species with altered abundances and specific functional pathways were found in OP individuals. The role of phytases in OP provides novel epidemiological evidence to elucidate the underlying microbiota-relevant mechanisms in bone mineralization and should be explored further. Frontiers Media S.A. 2021-11-18 /pmc/articles/PMC8638085/ /pubmed/34869341 http://dx.doi.org/10.3389/fcell.2021.752990 Text en Copyright © 2021 Qin, Yan, Yang, Chen, Yan, Li, Gao, Wang, Li, Wang and Ding. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Qin, Qian
Yan, Su
Yang, Yang
Chen, Jingfeng
Yan, Hang
Li, Tiantian
Gao, Xinxin
Wang, Youxiang
Li, Ang
Wang, Shoujun
Ding, Suying
The Relationship Between Osteoporosis and Intestinal Microbes in the Henan Province of China
title The Relationship Between Osteoporosis and Intestinal Microbes in the Henan Province of China
title_full The Relationship Between Osteoporosis and Intestinal Microbes in the Henan Province of China
title_fullStr The Relationship Between Osteoporosis and Intestinal Microbes in the Henan Province of China
title_full_unstemmed The Relationship Between Osteoporosis and Intestinal Microbes in the Henan Province of China
title_short The Relationship Between Osteoporosis and Intestinal Microbes in the Henan Province of China
title_sort relationship between osteoporosis and intestinal microbes in the henan province of china
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8638085/
https://www.ncbi.nlm.nih.gov/pubmed/34869341
http://dx.doi.org/10.3389/fcell.2021.752990
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