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An adaptive method of defining negative mutation status for multi-sample comparison using next-generation sequencing

BACKGROUND: Multi-sample comparison is commonly used in cancer genomics studies. By using next-generation sequencing (NGS), a mutation's status in a specific sample can be measured by the number of reads supporting mutant or wildtype alleles. When no mutant reads are detected, it could represen...

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Detalles Bibliográficos
Autores principales: Hutson, Nicholas, Zhan, Fenglin, Graham, James, Murakami, Mitsuko, Zhang, Han, Ganaparti, Sujana, Hu, Qiang, Yan, Li, Ma, Changxing, Liu, Song, Xie, Jun, Wei, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8638096/
https://www.ncbi.nlm.nih.gov/pubmed/34856988
http://dx.doi.org/10.1186/s12920-021-00880-8

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