A DNA adductome analysis revealed a reduction in the global level of C5-hydroxymethyl-2′-deoxycytidine in the non-tumoral upper urinary tract mucosa of urothelial carcinoma patients

BACKGROUND: DNA adducts, covalent modifications to DNA due to exposure to specific carcinogens, cause the mispairing of DNA bases, which ultimately results in DNA mutations. DNA methylation in the promoter region, another type of DNA base modification, alters the DNA transcription process, and has b...

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Detalles Bibliográficos
Autores principales: Matsushita, Yuto, Iwashita, Yuji, Ohtsuka, Shunsuke, Ohnishi, Ippei, Yamashita, Takashi, Miyake, Hideaki, Sugimura, Haruhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8638144/
https://www.ncbi.nlm.nih.gov/pubmed/34852853
http://dx.doi.org/10.1186/s41021-021-00228-9

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