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Dose-response association between device-measured physical activity and incident dementia: a prospective study from UK Biobank

BACKGROUND: Previous cohort studies have investigated the relationship between self-reported physical activity (PA) and dementia. Evidence from objective device-measured PA data is lacking. This study aimed to explore the association of device-measured PA with the risk of dementia incidence and comm...

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Autores principales: Petermann-Rocha, Fanny, Lyall, Donald M., Gray, Stuart R., Gill, Jason M. R., Sattar, Naveed, Welsh, Paul, Quinn, Terence J., Stewart, William, Pell, Jill P., Ho, Frederick K., Celis-Morales, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8638378/
https://www.ncbi.nlm.nih.gov/pubmed/34852818
http://dx.doi.org/10.1186/s12916-021-02172-5
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author Petermann-Rocha, Fanny
Lyall, Donald M.
Gray, Stuart R.
Gill, Jason M. R.
Sattar, Naveed
Welsh, Paul
Quinn, Terence J.
Stewart, William
Pell, Jill P.
Ho, Frederick K.
Celis-Morales, Carlos
author_facet Petermann-Rocha, Fanny
Lyall, Donald M.
Gray, Stuart R.
Gill, Jason M. R.
Sattar, Naveed
Welsh, Paul
Quinn, Terence J.
Stewart, William
Pell, Jill P.
Ho, Frederick K.
Celis-Morales, Carlos
author_sort Petermann-Rocha, Fanny
collection PubMed
description BACKGROUND: Previous cohort studies have investigated the relationship between self-reported physical activity (PA) and dementia. Evidence from objective device-measured PA data is lacking. This study aimed to explore the association of device-measured PA with the risk of dementia incidence and common subtypes (Alzheimer’s disease [AD] and vascular dementia) using the UK Biobank study. METHODS: 84,854 participants (55.8% women), invited to participate in the device-measured PA between 2013 and 2015, were included in this prospective cohort study. Wrist accelerometers were used to measure light, moderate, vigorous, moderate-to-vigorous PA (MVPA) and total PA intensity and duration (MET/min/week). Incident dementia (fatal and non-fatal) was extracted from hospital episodes records for incidence and death register for mortality. Incidence follow-up was carried out until the end of March 2021in England and Scotland and the end of March 2018 in Wales. Mortality data were available until February 2021. Nonlinear associations were first investigated using penalised cubic splines fitted in the Cox proportional hazard models. In addition, using MVPA, five categories were created. Associations of these categories with the outcomes were investigated using Cox proportional hazard models. Analyses were adjusted for sociodemographic, lifestyle and health-related factors. RESULTS: After a median follow-up of 6.3 years, 678 individuals were diagnosed with dementia. Evidence of nonlinearity was observed for all PA modes and all-cause dementia. For categories of MVPA, there was a significant trend towards a low risk of overall dementia when higher levels of MVPA were achieved (HR(trend) 0.66 [95% CI 0.62 to 0.70]. The lowest risk was identified in individuals who performed more than 1200 MET/min/week, those who had 84% (95% CI 0.12 to 0.21) lower risk of incident dementia compared to those who performed < 300 MET/min/week. CONCLUSIONS: Participants with higher PA levels had a lower risk of incident dementia than those less active, independently of sociodemographic, lifestyle factors and comorbidity. Considering that the majority of previous studies have reported this association using self-reported data, our findings highlight the strong inverse association between PA objectively measured and incident dementia. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12916-021-02172-5.
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spelling pubmed-86383782021-12-03 Dose-response association between device-measured physical activity and incident dementia: a prospective study from UK Biobank Petermann-Rocha, Fanny Lyall, Donald M. Gray, Stuart R. Gill, Jason M. R. Sattar, Naveed Welsh, Paul Quinn, Terence J. Stewart, William Pell, Jill P. Ho, Frederick K. Celis-Morales, Carlos BMC Med Research Article BACKGROUND: Previous cohort studies have investigated the relationship between self-reported physical activity (PA) and dementia. Evidence from objective device-measured PA data is lacking. This study aimed to explore the association of device-measured PA with the risk of dementia incidence and common subtypes (Alzheimer’s disease [AD] and vascular dementia) using the UK Biobank study. METHODS: 84,854 participants (55.8% women), invited to participate in the device-measured PA between 2013 and 2015, were included in this prospective cohort study. Wrist accelerometers were used to measure light, moderate, vigorous, moderate-to-vigorous PA (MVPA) and total PA intensity and duration (MET/min/week). Incident dementia (fatal and non-fatal) was extracted from hospital episodes records for incidence and death register for mortality. Incidence follow-up was carried out until the end of March 2021in England and Scotland and the end of March 2018 in Wales. Mortality data were available until February 2021. Nonlinear associations were first investigated using penalised cubic splines fitted in the Cox proportional hazard models. In addition, using MVPA, five categories were created. Associations of these categories with the outcomes were investigated using Cox proportional hazard models. Analyses were adjusted for sociodemographic, lifestyle and health-related factors. RESULTS: After a median follow-up of 6.3 years, 678 individuals were diagnosed with dementia. Evidence of nonlinearity was observed for all PA modes and all-cause dementia. For categories of MVPA, there was a significant trend towards a low risk of overall dementia when higher levels of MVPA were achieved (HR(trend) 0.66 [95% CI 0.62 to 0.70]. The lowest risk was identified in individuals who performed more than 1200 MET/min/week, those who had 84% (95% CI 0.12 to 0.21) lower risk of incident dementia compared to those who performed < 300 MET/min/week. CONCLUSIONS: Participants with higher PA levels had a lower risk of incident dementia than those less active, independently of sociodemographic, lifestyle factors and comorbidity. Considering that the majority of previous studies have reported this association using self-reported data, our findings highlight the strong inverse association between PA objectively measured and incident dementia. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12916-021-02172-5. BioMed Central 2021-12-02 /pmc/articles/PMC8638378/ /pubmed/34852818 http://dx.doi.org/10.1186/s12916-021-02172-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Petermann-Rocha, Fanny
Lyall, Donald M.
Gray, Stuart R.
Gill, Jason M. R.
Sattar, Naveed
Welsh, Paul
Quinn, Terence J.
Stewart, William
Pell, Jill P.
Ho, Frederick K.
Celis-Morales, Carlos
Dose-response association between device-measured physical activity and incident dementia: a prospective study from UK Biobank
title Dose-response association between device-measured physical activity and incident dementia: a prospective study from UK Biobank
title_full Dose-response association between device-measured physical activity and incident dementia: a prospective study from UK Biobank
title_fullStr Dose-response association between device-measured physical activity and incident dementia: a prospective study from UK Biobank
title_full_unstemmed Dose-response association between device-measured physical activity and incident dementia: a prospective study from UK Biobank
title_short Dose-response association between device-measured physical activity and incident dementia: a prospective study from UK Biobank
title_sort dose-response association between device-measured physical activity and incident dementia: a prospective study from uk biobank
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8638378/
https://www.ncbi.nlm.nih.gov/pubmed/34852818
http://dx.doi.org/10.1186/s12916-021-02172-5
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