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Switch receptor T3/28 improves long-term persistence and antitumor efficacy of CAR-T cells

BACKGROUND: Chimeric antigen receptor (CAR) T cells have been successfully used in tumor immunotherapy due to their strong antitumor responses, especially in hematological malignancies such as B cell acute lymphoid leukemia. However, on-target off-tumor toxicity and poor persistence severely limit t...

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Detalles Bibliográficos
Autores principales:	Zhao, Songbo, Wang, Chunhua, Lu, Ping, Lou, Yalin, Liu, Huimin, Wang, Ting, Yang, Shanshan, Bao, Ziyou, Han, Lin, Liang, Xiaohong, Ma, Chunhong, Gao, Lifen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2021
Materias:	Basic Tumor Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8638458/ https://www.ncbi.nlm.nih.gov/pubmed/34853180 http://dx.doi.org/10.1136/jitc-2021-003176

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