Deciphering the nonsense-mediated mRNA decay pathway to identify cancer cell vulnerabilities for effective cancer therapy

Nonsense-mediated mRNA decay (NMD) is a highly conserved cellular surveillance mechanism, commonly studied for its role in mRNA quality control because of its capacity of degrading mutated mRNAs that would produce truncated proteins. However, recent studies have proven that NMD hides more complex ta...

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Detalles Bibliográficos
Autores principales: Bongiorno, Roberta, Colombo, Mario Paolo, Lecis, Daniele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8638473/
https://www.ncbi.nlm.nih.gov/pubmed/34852841
http://dx.doi.org/10.1186/s13046-021-02192-2

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