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Extreme Exposure to Filtered Far‐UVC: A Case Study

Far‐UVC devices are being commercially sold as “safe for humans” for the inactivation of SARS‐CoV‐2, without supporting human safety data. We felt there was a need for rapid proof‐of‐concept human self‐exposure, to inform future controlled research and promote informed discussion. A Fitzpatrick Skin...

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Autores principales: Eadie, Ewan, Barnard, Isla M. R., Ibbotson, Sally H., Wood, Kenneth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8638665/
https://www.ncbi.nlm.nih.gov/pubmed/33471372
http://dx.doi.org/10.1111/php.13385
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author Eadie, Ewan
Barnard, Isla M. R.
Ibbotson, Sally H.
Wood, Kenneth
author_facet Eadie, Ewan
Barnard, Isla M. R.
Ibbotson, Sally H.
Wood, Kenneth
author_sort Eadie, Ewan
collection PubMed
description Far‐UVC devices are being commercially sold as “safe for humans” for the inactivation of SARS‐CoV‐2, without supporting human safety data. We felt there was a need for rapid proof‐of‐concept human self‐exposure, to inform future controlled research and promote informed discussion. A Fitzpatrick Skin Type II individual exposed their inner forearms to large radiant exposures from a filtered Krypton‐Chloride (KrCl) far‐UVC system (SafeZoneUVC, Ushio Inc., Tokyo, Japan) with peak emission at 222 nm. No visible skin changes were observed at 1500 mJ cm(−2); whereas, skin yellowing that appeared immediately and resolved within 24 h occurred with a 6000 mJ cm(−2) exposure. No erythema was observed at any time point with exposures up to 18 000 mJ cm(−2). These results combined with Monte Carlo Radiative Transfer computer modeling suggest that filtering longer ultraviolet wavelengths is critical for the human skin safety of far‐UVC devices. This work also contributes to growing arguments for the exploration of exposure limit expansion, which would subsequently enable faster inactivation of viruses.
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spelling pubmed-86386652021-12-09 Extreme Exposure to Filtered Far‐UVC: A Case Study Eadie, Ewan Barnard, Isla M. R. Ibbotson, Sally H. Wood, Kenneth Photochem Photobiol Special Issue Research Articles Far‐UVC devices are being commercially sold as “safe for humans” for the inactivation of SARS‐CoV‐2, without supporting human safety data. We felt there was a need for rapid proof‐of‐concept human self‐exposure, to inform future controlled research and promote informed discussion. A Fitzpatrick Skin Type II individual exposed their inner forearms to large radiant exposures from a filtered Krypton‐Chloride (KrCl) far‐UVC system (SafeZoneUVC, Ushio Inc., Tokyo, Japan) with peak emission at 222 nm. No visible skin changes were observed at 1500 mJ cm(−2); whereas, skin yellowing that appeared immediately and resolved within 24 h occurred with a 6000 mJ cm(−2) exposure. No erythema was observed at any time point with exposures up to 18 000 mJ cm(−2). These results combined with Monte Carlo Radiative Transfer computer modeling suggest that filtering longer ultraviolet wavelengths is critical for the human skin safety of far‐UVC devices. This work also contributes to growing arguments for the exploration of exposure limit expansion, which would subsequently enable faster inactivation of viruses. John Wiley and Sons Inc. 2021-02-03 2021 /pmc/articles/PMC8638665/ /pubmed/33471372 http://dx.doi.org/10.1111/php.13385 Text en © 2021 The Authors. Photochemistry and Photobiology published by Wiley Periodicals LLC on behalf of American Society for Photobiology https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Special Issue Research Articles
Eadie, Ewan
Barnard, Isla M. R.
Ibbotson, Sally H.
Wood, Kenneth
Extreme Exposure to Filtered Far‐UVC: A Case Study
title Extreme Exposure to Filtered Far‐UVC: A Case Study
title_full Extreme Exposure to Filtered Far‐UVC: A Case Study
title_fullStr Extreme Exposure to Filtered Far‐UVC: A Case Study
title_full_unstemmed Extreme Exposure to Filtered Far‐UVC: A Case Study
title_short Extreme Exposure to Filtered Far‐UVC: A Case Study
title_sort extreme exposure to filtered far‐uvc: a case study
topic Special Issue Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8638665/
https://www.ncbi.nlm.nih.gov/pubmed/33471372
http://dx.doi.org/10.1111/php.13385
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