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Ribosome dysfunction in osteoarthritis

Translation of genetic information encoded within mRNA molecules by ribosomes into proteins is a key part of the central dogma of molecular biology. Despite the central position of the ribosome in the translation of proteins, and considering the major proteomic changes that occur in the joint during...

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Autores principales: van den Akker, Guus G.H., Caron, Marjolein M.J., Peffers, Mandy J., Welting, Tim J.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8638817/
https://www.ncbi.nlm.nih.gov/pubmed/34750309
http://dx.doi.org/10.1097/BOR.0000000000000858
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author van den Akker, Guus G.H.
Caron, Marjolein M.J.
Peffers, Mandy J.
Welting, Tim J.M.
author_facet van den Akker, Guus G.H.
Caron, Marjolein M.J.
Peffers, Mandy J.
Welting, Tim J.M.
author_sort van den Akker, Guus G.H.
collection PubMed
description Translation of genetic information encoded within mRNA molecules by ribosomes into proteins is a key part of the central dogma of molecular biology. Despite the central position of the ribosome in the translation of proteins, and considering the major proteomic changes that occur in the joint during osteoarthritis development and progression, the ribosome has received very limited attention as driver of osteoarthritis pathogenesis. RECENT FINDINGS: We provide an overview of the limited literature regarding this developing topic for the osteoarthritis field. Recent key findings that connect ribosome biogenesis and activity with osteoarthritis include: ribosomal RNA transcription, processing and maturation, ribosomal protein expression, protein translation capacity and preferential translation. SUMMARY: The ribosome as the central cellular protein synthesis hub is largely neglected in osteoarthritis research. Findings included in this review reveal that in osteoarthritis, ribosome aberrations have been found from early-stage ribosome biogenesis, through ribosome build-up and maturation, up to preferential translation. Classically, osteoarthritis has been explained as an imbalance between joint tissue anabolism and catabolism. We postulate that osteoarthritis can be interpreted as an acquired ribosomopathy. This hypothesis fine-tunes the dogmatic anabolism/katabolism point-of-view, and may provide novel molecular opportunities for the development of osteoarthritis disease-modifying treatments.
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spelling pubmed-86388172021-12-07 Ribosome dysfunction in osteoarthritis van den Akker, Guus G.H. Caron, Marjolein M.J. Peffers, Mandy J. Welting, Tim J.M. Curr Opin Rheumatol OSTEOARTHRITIS: Edited by Mukundan Attur Translation of genetic information encoded within mRNA molecules by ribosomes into proteins is a key part of the central dogma of molecular biology. Despite the central position of the ribosome in the translation of proteins, and considering the major proteomic changes that occur in the joint during osteoarthritis development and progression, the ribosome has received very limited attention as driver of osteoarthritis pathogenesis. RECENT FINDINGS: We provide an overview of the limited literature regarding this developing topic for the osteoarthritis field. Recent key findings that connect ribosome biogenesis and activity with osteoarthritis include: ribosomal RNA transcription, processing and maturation, ribosomal protein expression, protein translation capacity and preferential translation. SUMMARY: The ribosome as the central cellular protein synthesis hub is largely neglected in osteoarthritis research. Findings included in this review reveal that in osteoarthritis, ribosome aberrations have been found from early-stage ribosome biogenesis, through ribosome build-up and maturation, up to preferential translation. Classically, osteoarthritis has been explained as an imbalance between joint tissue anabolism and catabolism. We postulate that osteoarthritis can be interpreted as an acquired ribosomopathy. This hypothesis fine-tunes the dogmatic anabolism/katabolism point-of-view, and may provide novel molecular opportunities for the development of osteoarthritis disease-modifying treatments. Lippincott Williams & Wilkins 2022-01 2021-11-25 /pmc/articles/PMC8638817/ /pubmed/34750309 http://dx.doi.org/10.1097/BOR.0000000000000858 Text en Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/)
spellingShingle OSTEOARTHRITIS: Edited by Mukundan Attur
van den Akker, Guus G.H.
Caron, Marjolein M.J.
Peffers, Mandy J.
Welting, Tim J.M.
Ribosome dysfunction in osteoarthritis
title Ribosome dysfunction in osteoarthritis
title_full Ribosome dysfunction in osteoarthritis
title_fullStr Ribosome dysfunction in osteoarthritis
title_full_unstemmed Ribosome dysfunction in osteoarthritis
title_short Ribosome dysfunction in osteoarthritis
title_sort ribosome dysfunction in osteoarthritis
topic OSTEOARTHRITIS: Edited by Mukundan Attur
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8638817/
https://www.ncbi.nlm.nih.gov/pubmed/34750309
http://dx.doi.org/10.1097/BOR.0000000000000858
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