Cargando…

Relationships of sex hormones with muscle mass and muscle strength in male adolescents at different stages of puberty

This study analysed the associations of sex steroids with fat-free mass (FFM) and handgrip strength in 641 Chinese boys. Serum total testosterone (TT) and oestradiol were measured by chemiluminescence immunoassay. Free testosterone (FT) and oestradiol were calculated. FFM and handgrip strength were...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Yang, Wen, Zhigang, Deng, Kaili, Li, Ran, Yu, Qing, Xiao, Su-Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8638900/
https://www.ncbi.nlm.nih.gov/pubmed/34855818
http://dx.doi.org/10.1371/journal.pone.0260521
_version_ 1784609036304384000
author Xu, Yang
Wen, Zhigang
Deng, Kaili
Li, Ran
Yu, Qing
Xiao, Su-Mei
author_facet Xu, Yang
Wen, Zhigang
Deng, Kaili
Li, Ran
Yu, Qing
Xiao, Su-Mei
author_sort Xu, Yang
collection PubMed
description This study analysed the associations of sex steroids with fat-free mass (FFM) and handgrip strength in 641 Chinese boys. Serum total testosterone (TT) and oestradiol were measured by chemiluminescence immunoassay. Free testosterone (FT) and oestradiol were calculated. FFM and handgrip strength were measured by bioelectrical impedance analysis and a hand dynamometer, respectively. Generalised additive models and multiple linear regression were used to explore the relationships. A subgroup analysis was conducted in early-mid pubertal and late-post pubertal groups. Age, height, weight, physical activity, intake of dietary protein and/or stage of puberty were adjusted. TT and FT were positively related to FFM and handgrip strength, with a curvilinear relationship being detected for handgrip strength (p<0.050). This curvilinear relationship was only observed in the late-post pubertal group, suggesting a potential threshold effect (FT>11.99ng/dL, β = 1.275, p = 0.039). In the early-mid pubertal group, TT and/or FT were linearly or near-linearly related to FFM or handgrip strength (β = 0.003–0.271, p<0.050). The association between FT and FFM was stronger than that in the late-post pubertal group. This study found that serum T had different associations with muscle parameters in Chinese early-mid pubertal and late-post pubertal boys. In the late-post pubertal boys, serum T was curvilinearly related to muscle strength with a threshold effect and its link with muscle mass was weaker.
format Online
Article
Text
id pubmed-8638900
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-86389002021-12-03 Relationships of sex hormones with muscle mass and muscle strength in male adolescents at different stages of puberty Xu, Yang Wen, Zhigang Deng, Kaili Li, Ran Yu, Qing Xiao, Su-Mei PLoS One Research Article This study analysed the associations of sex steroids with fat-free mass (FFM) and handgrip strength in 641 Chinese boys. Serum total testosterone (TT) and oestradiol were measured by chemiluminescence immunoassay. Free testosterone (FT) and oestradiol were calculated. FFM and handgrip strength were measured by bioelectrical impedance analysis and a hand dynamometer, respectively. Generalised additive models and multiple linear regression were used to explore the relationships. A subgroup analysis was conducted in early-mid pubertal and late-post pubertal groups. Age, height, weight, physical activity, intake of dietary protein and/or stage of puberty were adjusted. TT and FT were positively related to FFM and handgrip strength, with a curvilinear relationship being detected for handgrip strength (p<0.050). This curvilinear relationship was only observed in the late-post pubertal group, suggesting a potential threshold effect (FT>11.99ng/dL, β = 1.275, p = 0.039). In the early-mid pubertal group, TT and/or FT were linearly or near-linearly related to FFM or handgrip strength (β = 0.003–0.271, p<0.050). The association between FT and FFM was stronger than that in the late-post pubertal group. This study found that serum T had different associations with muscle parameters in Chinese early-mid pubertal and late-post pubertal boys. In the late-post pubertal boys, serum T was curvilinearly related to muscle strength with a threshold effect and its link with muscle mass was weaker. Public Library of Science 2021-12-02 /pmc/articles/PMC8638900/ /pubmed/34855818 http://dx.doi.org/10.1371/journal.pone.0260521 Text en © 2021 Xu et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Xu, Yang
Wen, Zhigang
Deng, Kaili
Li, Ran
Yu, Qing
Xiao, Su-Mei
Relationships of sex hormones with muscle mass and muscle strength in male adolescents at different stages of puberty
title Relationships of sex hormones with muscle mass and muscle strength in male adolescents at different stages of puberty
title_full Relationships of sex hormones with muscle mass and muscle strength in male adolescents at different stages of puberty
title_fullStr Relationships of sex hormones with muscle mass and muscle strength in male adolescents at different stages of puberty
title_full_unstemmed Relationships of sex hormones with muscle mass and muscle strength in male adolescents at different stages of puberty
title_short Relationships of sex hormones with muscle mass and muscle strength in male adolescents at different stages of puberty
title_sort relationships of sex hormones with muscle mass and muscle strength in male adolescents at different stages of puberty
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8638900/
https://www.ncbi.nlm.nih.gov/pubmed/34855818
http://dx.doi.org/10.1371/journal.pone.0260521
work_keys_str_mv AT xuyang relationshipsofsexhormoneswithmusclemassandmusclestrengthinmaleadolescentsatdifferentstagesofpuberty
AT wenzhigang relationshipsofsexhormoneswithmusclemassandmusclestrengthinmaleadolescentsatdifferentstagesofpuberty
AT dengkaili relationshipsofsexhormoneswithmusclemassandmusclestrengthinmaleadolescentsatdifferentstagesofpuberty
AT liran relationshipsofsexhormoneswithmusclemassandmusclestrengthinmaleadolescentsatdifferentstagesofpuberty
AT yuqing relationshipsofsexhormoneswithmusclemassandmusclestrengthinmaleadolescentsatdifferentstagesofpuberty
AT xiaosumei relationshipsofsexhormoneswithmusclemassandmusclestrengthinmaleadolescentsatdifferentstagesofpuberty