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Relationships of sex hormones with muscle mass and muscle strength in male adolescents at different stages of puberty
This study analysed the associations of sex steroids with fat-free mass (FFM) and handgrip strength in 641 Chinese boys. Serum total testosterone (TT) and oestradiol were measured by chemiluminescence immunoassay. Free testosterone (FT) and oestradiol were calculated. FFM and handgrip strength were...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8638900/ https://www.ncbi.nlm.nih.gov/pubmed/34855818 http://dx.doi.org/10.1371/journal.pone.0260521 |
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author | Xu, Yang Wen, Zhigang Deng, Kaili Li, Ran Yu, Qing Xiao, Su-Mei |
author_facet | Xu, Yang Wen, Zhigang Deng, Kaili Li, Ran Yu, Qing Xiao, Su-Mei |
author_sort | Xu, Yang |
collection | PubMed |
description | This study analysed the associations of sex steroids with fat-free mass (FFM) and handgrip strength in 641 Chinese boys. Serum total testosterone (TT) and oestradiol were measured by chemiluminescence immunoassay. Free testosterone (FT) and oestradiol were calculated. FFM and handgrip strength were measured by bioelectrical impedance analysis and a hand dynamometer, respectively. Generalised additive models and multiple linear regression were used to explore the relationships. A subgroup analysis was conducted in early-mid pubertal and late-post pubertal groups. Age, height, weight, physical activity, intake of dietary protein and/or stage of puberty were adjusted. TT and FT were positively related to FFM and handgrip strength, with a curvilinear relationship being detected for handgrip strength (p<0.050). This curvilinear relationship was only observed in the late-post pubertal group, suggesting a potential threshold effect (FT>11.99ng/dL, β = 1.275, p = 0.039). In the early-mid pubertal group, TT and/or FT were linearly or near-linearly related to FFM or handgrip strength (β = 0.003–0.271, p<0.050). The association between FT and FFM was stronger than that in the late-post pubertal group. This study found that serum T had different associations with muscle parameters in Chinese early-mid pubertal and late-post pubertal boys. In the late-post pubertal boys, serum T was curvilinearly related to muscle strength with a threshold effect and its link with muscle mass was weaker. |
format | Online Article Text |
id | pubmed-8638900 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-86389002021-12-03 Relationships of sex hormones with muscle mass and muscle strength in male adolescents at different stages of puberty Xu, Yang Wen, Zhigang Deng, Kaili Li, Ran Yu, Qing Xiao, Su-Mei PLoS One Research Article This study analysed the associations of sex steroids with fat-free mass (FFM) and handgrip strength in 641 Chinese boys. Serum total testosterone (TT) and oestradiol were measured by chemiluminescence immunoassay. Free testosterone (FT) and oestradiol were calculated. FFM and handgrip strength were measured by bioelectrical impedance analysis and a hand dynamometer, respectively. Generalised additive models and multiple linear regression were used to explore the relationships. A subgroup analysis was conducted in early-mid pubertal and late-post pubertal groups. Age, height, weight, physical activity, intake of dietary protein and/or stage of puberty were adjusted. TT and FT were positively related to FFM and handgrip strength, with a curvilinear relationship being detected for handgrip strength (p<0.050). This curvilinear relationship was only observed in the late-post pubertal group, suggesting a potential threshold effect (FT>11.99ng/dL, β = 1.275, p = 0.039). In the early-mid pubertal group, TT and/or FT were linearly or near-linearly related to FFM or handgrip strength (β = 0.003–0.271, p<0.050). The association between FT and FFM was stronger than that in the late-post pubertal group. This study found that serum T had different associations with muscle parameters in Chinese early-mid pubertal and late-post pubertal boys. In the late-post pubertal boys, serum T was curvilinearly related to muscle strength with a threshold effect and its link with muscle mass was weaker. Public Library of Science 2021-12-02 /pmc/articles/PMC8638900/ /pubmed/34855818 http://dx.doi.org/10.1371/journal.pone.0260521 Text en © 2021 Xu et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Xu, Yang Wen, Zhigang Deng, Kaili Li, Ran Yu, Qing Xiao, Su-Mei Relationships of sex hormones with muscle mass and muscle strength in male adolescents at different stages of puberty |
title | Relationships of sex hormones with muscle mass and muscle strength in male adolescents at different stages of puberty |
title_full | Relationships of sex hormones with muscle mass and muscle strength in male adolescents at different stages of puberty |
title_fullStr | Relationships of sex hormones with muscle mass and muscle strength in male adolescents at different stages of puberty |
title_full_unstemmed | Relationships of sex hormones with muscle mass and muscle strength in male adolescents at different stages of puberty |
title_short | Relationships of sex hormones with muscle mass and muscle strength in male adolescents at different stages of puberty |
title_sort | relationships of sex hormones with muscle mass and muscle strength in male adolescents at different stages of puberty |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8638900/ https://www.ncbi.nlm.nih.gov/pubmed/34855818 http://dx.doi.org/10.1371/journal.pone.0260521 |
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