Intratumoral expression of IL-12 from lentiviral or RNA vectors acts synergistically with TLR4 agonist (GLA) to generate anti-tumor immunological memory

Systemic interleukin-12 (IL12) anti-tumor therapy is highly potent but has had limited utility in the clinic due to severe toxicity. Here, we present two IL12-expressing vector platforms, both of which can overcome the deficiencies of previous systemic IL12 therapies: 1) an integrating lentiviral ve...

Descripción completa

Detalles Bibliográficos
Autores principales: Leleux, Jardin A., Albershardt, Tina C., Reeves, Rebecca, James, Reice, Krull, Jordan, Parsons, Andrea J., ter Meulen, Jan, Berglund, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8638928/
https://www.ncbi.nlm.nih.gov/pubmed/34855754
http://dx.doi.org/10.1371/journal.pone.0259301

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8638928/
https://www.ncbi.nlm.nih.gov/pubmed/34855754
http://dx.doi.org/10.1371/journal.pone.0259301

Ejemplares similares