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Longitudinal trajectories of blood lipid levels in an ageing population sample of Russian Western-Siberian urban population
This study investigated 12-year blood lipid trajectories and whether these trajectories are modified by smoking and lipid lowering treatment in older Russians. To do so, we analysed data on 9,218 Russian West-Siberian Caucasians aged 45–69 years at baseline participating in the international HAPIEE...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8638938/ https://www.ncbi.nlm.nih.gov/pubmed/34855783 http://dx.doi.org/10.1371/journal.pone.0260229 |
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author | Hubacek, Jaroslav A. Nikitin, Yuri Ragino, Yulia Stakhneva, Ekaterina Pikhart, Hynek Peasey, Anne Holmes, Michael V. Stefler, Denes Ryabikov, Andrey Verevkin, Eugeny Bobak, Martin Malyutina, Sofia |
author_facet | Hubacek, Jaroslav A. Nikitin, Yuri Ragino, Yulia Stakhneva, Ekaterina Pikhart, Hynek Peasey, Anne Holmes, Michael V. Stefler, Denes Ryabikov, Andrey Verevkin, Eugeny Bobak, Martin Malyutina, Sofia |
author_sort | Hubacek, Jaroslav A. |
collection | PubMed |
description | This study investigated 12-year blood lipid trajectories and whether these trajectories are modified by smoking and lipid lowering treatment in older Russians. To do so, we analysed data on 9,218 Russian West-Siberian Caucasians aged 45–69 years at baseline participating in the international HAPIEE cohort study. Mixed-effect multilevel models were used to estimate individual level lipid trajectories across the baseline and two follow-up examinations (16,445 separate measurements over 12 years). In all age groups, we observed a reduction in serum total cholesterol (TC), LDL-C and non-HDL-C over time even after adjusting for sex, statin treatment, hypertension, diabetes, social factors and mortality (P<0.01). In contrast, serum triglyceride (TG) values increased over time in younger age groups, reached a plateau and decreased in older age groups (> 60 years at baseline). In smokers, TC, LDL-C, non-HDL-C and TG decreased less markedly than in non-smokers, while HDL-C decreased more rapidly while the LDL-C/HDL-C ratio increased. In subjects treated with lipid-lowering drugs, TC, LDL-C and non-HDL-C decreased more markedly and HDL-C less markedly than in untreated subjects while TG and LDL-C/HDL-C remained stable or increased in treatment naïve subjects. We conclude, that in this ageing population we observed marked changes in blood lipids over a 12 year follow up, with decreasing trajectories of TC, LDL-C and non-HDL-C and mixed trajectories of TG. The findings suggest that monitoring of age-related trajectories in blood lipids may improve prediction of CVD risk beyond single measurements. |
format | Online Article Text |
id | pubmed-8638938 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-86389382021-12-03 Longitudinal trajectories of blood lipid levels in an ageing population sample of Russian Western-Siberian urban population Hubacek, Jaroslav A. Nikitin, Yuri Ragino, Yulia Stakhneva, Ekaterina Pikhart, Hynek Peasey, Anne Holmes, Michael V. Stefler, Denes Ryabikov, Andrey Verevkin, Eugeny Bobak, Martin Malyutina, Sofia PLoS One Research Article This study investigated 12-year blood lipid trajectories and whether these trajectories are modified by smoking and lipid lowering treatment in older Russians. To do so, we analysed data on 9,218 Russian West-Siberian Caucasians aged 45–69 years at baseline participating in the international HAPIEE cohort study. Mixed-effect multilevel models were used to estimate individual level lipid trajectories across the baseline and two follow-up examinations (16,445 separate measurements over 12 years). In all age groups, we observed a reduction in serum total cholesterol (TC), LDL-C and non-HDL-C over time even after adjusting for sex, statin treatment, hypertension, diabetes, social factors and mortality (P<0.01). In contrast, serum triglyceride (TG) values increased over time in younger age groups, reached a plateau and decreased in older age groups (> 60 years at baseline). In smokers, TC, LDL-C, non-HDL-C and TG decreased less markedly than in non-smokers, while HDL-C decreased more rapidly while the LDL-C/HDL-C ratio increased. In subjects treated with lipid-lowering drugs, TC, LDL-C and non-HDL-C decreased more markedly and HDL-C less markedly than in untreated subjects while TG and LDL-C/HDL-C remained stable or increased in treatment naïve subjects. We conclude, that in this ageing population we observed marked changes in blood lipids over a 12 year follow up, with decreasing trajectories of TC, LDL-C and non-HDL-C and mixed trajectories of TG. The findings suggest that monitoring of age-related trajectories in blood lipids may improve prediction of CVD risk beyond single measurements. Public Library of Science 2021-12-02 /pmc/articles/PMC8638938/ /pubmed/34855783 http://dx.doi.org/10.1371/journal.pone.0260229 Text en © 2021 Hubacek et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Hubacek, Jaroslav A. Nikitin, Yuri Ragino, Yulia Stakhneva, Ekaterina Pikhart, Hynek Peasey, Anne Holmes, Michael V. Stefler, Denes Ryabikov, Andrey Verevkin, Eugeny Bobak, Martin Malyutina, Sofia Longitudinal trajectories of blood lipid levels in an ageing population sample of Russian Western-Siberian urban population |
title | Longitudinal trajectories of blood lipid levels in an ageing population sample of Russian Western-Siberian urban population |
title_full | Longitudinal trajectories of blood lipid levels in an ageing population sample of Russian Western-Siberian urban population |
title_fullStr | Longitudinal trajectories of blood lipid levels in an ageing population sample of Russian Western-Siberian urban population |
title_full_unstemmed | Longitudinal trajectories of blood lipid levels in an ageing population sample of Russian Western-Siberian urban population |
title_short | Longitudinal trajectories of blood lipid levels in an ageing population sample of Russian Western-Siberian urban population |
title_sort | longitudinal trajectories of blood lipid levels in an ageing population sample of russian western-siberian urban population |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8638938/ https://www.ncbi.nlm.nih.gov/pubmed/34855783 http://dx.doi.org/10.1371/journal.pone.0260229 |
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