Assessing BRCA1 activity in DNA damage repair using human induced pluripotent stem cells as an approach to assist classification of BRCA1 variants of uncertain significance

Establishing a universally applicable protocol to assess the impact of BRCA1 variants of uncertain significance (VUS) expression is a problem which has yet to be resolved despite major progresses have been made. The numerous difficulties which must be overcome include the choices of cellular models...

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Detalles Bibliográficos
Autores principales: Ozgencil, Meryem, Barwell, Julian, Tischkowitz, Marc, Izatt, Louise, Kesterton, Ian, Simpson, Michael, Sharpe, Paul, de Sepulveda, Paulo, Voisset, Edwige, Solomon, Ellen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8638976/
https://www.ncbi.nlm.nih.gov/pubmed/34855882
http://dx.doi.org/10.1371/journal.pone.0260852

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