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ThinPrep cytology combined with HPV detection in the diagnosis of cervical lesions in 1622 patients

The timely detection of precancerous lesions and early intervention can greatly reduce cervical cancer occurrence. The current study aimed to assess the diagnostic value and accuracy of different methods of cervical lesion screening. A total of 1622 females who visited the Outpatient Department of X...

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Autores principales: Husaiyin, Sulaiya, Jiao, Zhen, Yimamu, Kailibinuer, Maisaidi, Reyilanmu, Han, Lili, Niyazi, Mayinuer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8638999/
https://www.ncbi.nlm.nih.gov/pubmed/34855928
http://dx.doi.org/10.1371/journal.pone.0260915
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author Husaiyin, Sulaiya
Jiao, Zhen
Yimamu, Kailibinuer
Maisaidi, Reyilanmu
Han, Lili
Niyazi, Mayinuer
author_facet Husaiyin, Sulaiya
Jiao, Zhen
Yimamu, Kailibinuer
Maisaidi, Reyilanmu
Han, Lili
Niyazi, Mayinuer
author_sort Husaiyin, Sulaiya
collection PubMed
description The timely detection of precancerous lesions and early intervention can greatly reduce cervical cancer occurrence. The current study aimed to assess the diagnostic value and accuracy of different methods of cervical lesion screening. A total of 1622 females who visited the Outpatient Department of Xinjiang Uyghur Autonomous Region People’s Hospital between January and December 2018 were consecutively enrolled. All participants underwent separate high-risk human papilloma virus (HR-HPV) DNA detection, ThinPrep cytology testing (TCT) and colposcopic biopsy. Their medical records were retrospectively analyzed. While considering biopsy outcomes as the gold standard, the diagnostic values of TCT, HR-HPV testing, and TCT+HR-HPV testing for cervical cancer screening were compared. The sensitivity, specificity and Youden index of each method were calculated. Among the different methods, TCT+HR-HPV testing had the highest sensitivity (89.8%), followed by TCT (79.9%) and HR-HPV testing (49.2%). The combined method also had the highest Youden value, and its screening outcomes exhibited the highest consistency with those of biopsy. In addition, the combined method had the largest area under the receiver operating characteristic (ROC) curve, which was 0.673 (0.647, 0.699), compared with any other screening method. Compared with TCT or HR-HPV testing alone, TCT+HR-HPV testing serves as a better screening method for cervical cancer and precancerous lesions.
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spelling pubmed-86389992021-12-03 ThinPrep cytology combined with HPV detection in the diagnosis of cervical lesions in 1622 patients Husaiyin, Sulaiya Jiao, Zhen Yimamu, Kailibinuer Maisaidi, Reyilanmu Han, Lili Niyazi, Mayinuer PLoS One Research Article The timely detection of precancerous lesions and early intervention can greatly reduce cervical cancer occurrence. The current study aimed to assess the diagnostic value and accuracy of different methods of cervical lesion screening. A total of 1622 females who visited the Outpatient Department of Xinjiang Uyghur Autonomous Region People’s Hospital between January and December 2018 were consecutively enrolled. All participants underwent separate high-risk human papilloma virus (HR-HPV) DNA detection, ThinPrep cytology testing (TCT) and colposcopic biopsy. Their medical records were retrospectively analyzed. While considering biopsy outcomes as the gold standard, the diagnostic values of TCT, HR-HPV testing, and TCT+HR-HPV testing for cervical cancer screening were compared. The sensitivity, specificity and Youden index of each method were calculated. Among the different methods, TCT+HR-HPV testing had the highest sensitivity (89.8%), followed by TCT (79.9%) and HR-HPV testing (49.2%). The combined method also had the highest Youden value, and its screening outcomes exhibited the highest consistency with those of biopsy. In addition, the combined method had the largest area under the receiver operating characteristic (ROC) curve, which was 0.673 (0.647, 0.699), compared with any other screening method. Compared with TCT or HR-HPV testing alone, TCT+HR-HPV testing serves as a better screening method for cervical cancer and precancerous lesions. Public Library of Science 2021-12-02 /pmc/articles/PMC8638999/ /pubmed/34855928 http://dx.doi.org/10.1371/journal.pone.0260915 Text en © 2021 Husaiyin et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Husaiyin, Sulaiya
Jiao, Zhen
Yimamu, Kailibinuer
Maisaidi, Reyilanmu
Han, Lili
Niyazi, Mayinuer
ThinPrep cytology combined with HPV detection in the diagnosis of cervical lesions in 1622 patients
title ThinPrep cytology combined with HPV detection in the diagnosis of cervical lesions in 1622 patients
title_full ThinPrep cytology combined with HPV detection in the diagnosis of cervical lesions in 1622 patients
title_fullStr ThinPrep cytology combined with HPV detection in the diagnosis of cervical lesions in 1622 patients
title_full_unstemmed ThinPrep cytology combined with HPV detection in the diagnosis of cervical lesions in 1622 patients
title_short ThinPrep cytology combined with HPV detection in the diagnosis of cervical lesions in 1622 patients
title_sort thinprep cytology combined with hpv detection in the diagnosis of cervical lesions in 1622 patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8638999/
https://www.ncbi.nlm.nih.gov/pubmed/34855928
http://dx.doi.org/10.1371/journal.pone.0260915
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