An HLA-I signature favouring KIR-educated Natural Killer cells mediates immune control of HIV in children and contrasts with the HLA-B-restricted CD8+ T-cell-mediated immune control in adults

Natural Killer (NK) cells contribute to HIV control in adults, but HLA-B-mediated T-cell activity has a more substantial impact on disease outcome. However, the HLA-B molecules influencing immune control in adults have less impact on paediatric infection. To investigate the contribution NK cells mak...

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Detalles Bibliográficos
Autores principales: Vieira, Vinicius A., Adland, Emily, Malone, David F. G., Martin, Maureen P., Groll, Andreas, Ansari, M. Azim, Garcia-Guerrero, Maria C., Puertas, Mari C., Muenchhoff, Maximilian, Guash, Claudia Fortuny, Brander, Christian, Martinez-Picado, Javier, Bamford, Alasdair, Tudor-Williams, Gareth, Ndung’u, Thumbi, Walker, Bruce D., Ramsuran, Veron, Frater, John, Jooste, Pieter, Peppa, Dimitra, Carrington, Mary, Goulder, Philip J. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639058/
https://www.ncbi.nlm.nih.gov/pubmed/34793581
http://dx.doi.org/10.1371/journal.ppat.1010090

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