Niclosamide shows strong antiviral activity in a human airway model of SARS-CoV-2 infection and a conserved potency against the Alpha (B.1.1.7), Beta (B.1.351) and Delta variant (B.1.617.2)

SARS-CoV-2 variants are emerging with potential increased transmissibility highlighting the great unmet medical need for new therapies. Niclosamide is a potent anti-SARS-CoV-2 agent that has advanced in clinical development. We validate the potent antiviral efficacy of niclosamide in a SARS-CoV-2 hu...

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Autores principales: Weiss, Anne, Touret, Franck, Baronti, Cecile, Gilles, Magali, Hoen, Bruno, Nougairède, Antoine, de Lamballerie, Xavier, Sommer, Morten O. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639074/
https://www.ncbi.nlm.nih.gov/pubmed/34855904
http://dx.doi.org/10.1371/journal.pone.0260958
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author Weiss, Anne
Touret, Franck
Baronti, Cecile
Gilles, Magali
Hoen, Bruno
Nougairède, Antoine
de Lamballerie, Xavier
Sommer, Morten O. A.
author_facet Weiss, Anne
Touret, Franck
Baronti, Cecile
Gilles, Magali
Hoen, Bruno
Nougairède, Antoine
de Lamballerie, Xavier
Sommer, Morten O. A.
author_sort Weiss, Anne
collection PubMed
description SARS-CoV-2 variants are emerging with potential increased transmissibility highlighting the great unmet medical need for new therapies. Niclosamide is a potent anti-SARS-CoV-2 agent that has advanced in clinical development. We validate the potent antiviral efficacy of niclosamide in a SARS-CoV-2 human airway model. Furthermore, niclosamide remains its potency against the D614G, Alpha (B.1.1.7), Beta (B.1.351), and Delta (B.1.617.2) variants. Our data further support the potent anti-SARS-CoV-2 properties of niclosamide and highlights its great potential as a therapeutic agent for COVID-19.
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spelling pubmed-86390742021-12-03 Niclosamide shows strong antiviral activity in a human airway model of SARS-CoV-2 infection and a conserved potency against the Alpha (B.1.1.7), Beta (B.1.351) and Delta variant (B.1.617.2) Weiss, Anne Touret, Franck Baronti, Cecile Gilles, Magali Hoen, Bruno Nougairède, Antoine de Lamballerie, Xavier Sommer, Morten O. A. PLoS One Research Article SARS-CoV-2 variants are emerging with potential increased transmissibility highlighting the great unmet medical need for new therapies. Niclosamide is a potent anti-SARS-CoV-2 agent that has advanced in clinical development. We validate the potent antiviral efficacy of niclosamide in a SARS-CoV-2 human airway model. Furthermore, niclosamide remains its potency against the D614G, Alpha (B.1.1.7), Beta (B.1.351), and Delta (B.1.617.2) variants. Our data further support the potent anti-SARS-CoV-2 properties of niclosamide and highlights its great potential as a therapeutic agent for COVID-19. Public Library of Science 2021-12-02 /pmc/articles/PMC8639074/ /pubmed/34855904 http://dx.doi.org/10.1371/journal.pone.0260958 Text en © 2021 Weiss et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Weiss, Anne
Touret, Franck
Baronti, Cecile
Gilles, Magali
Hoen, Bruno
Nougairède, Antoine
de Lamballerie, Xavier
Sommer, Morten O. A.
Niclosamide shows strong antiviral activity in a human airway model of SARS-CoV-2 infection and a conserved potency against the Alpha (B.1.1.7), Beta (B.1.351) and Delta variant (B.1.617.2)
title Niclosamide shows strong antiviral activity in a human airway model of SARS-CoV-2 infection and a conserved potency against the Alpha (B.1.1.7), Beta (B.1.351) and Delta variant (B.1.617.2)
title_full Niclosamide shows strong antiviral activity in a human airway model of SARS-CoV-2 infection and a conserved potency against the Alpha (B.1.1.7), Beta (B.1.351) and Delta variant (B.1.617.2)
title_fullStr Niclosamide shows strong antiviral activity in a human airway model of SARS-CoV-2 infection and a conserved potency against the Alpha (B.1.1.7), Beta (B.1.351) and Delta variant (B.1.617.2)
title_full_unstemmed Niclosamide shows strong antiviral activity in a human airway model of SARS-CoV-2 infection and a conserved potency against the Alpha (B.1.1.7), Beta (B.1.351) and Delta variant (B.1.617.2)
title_short Niclosamide shows strong antiviral activity in a human airway model of SARS-CoV-2 infection and a conserved potency against the Alpha (B.1.1.7), Beta (B.1.351) and Delta variant (B.1.617.2)
title_sort niclosamide shows strong antiviral activity in a human airway model of sars-cov-2 infection and a conserved potency against the alpha (b.1.1.7), beta (b.1.351) and delta variant (b.1.617.2)
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639074/
https://www.ncbi.nlm.nih.gov/pubmed/34855904
http://dx.doi.org/10.1371/journal.pone.0260958
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