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Nucleoporin TPR promotes tRNA nuclear export and protein synthesis in lung cancer cells

The robust proliferation of cancer cells requires vastly elevated levels of protein synthesis, which relies on a steady supply of aminoacylated tRNAs. Delivery of tRNAs to the cytoplasm is a highly regulated process, but the machinery for tRNA nuclear export is not fully elucidated. In this study, u...

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Detalles Bibliográficos
Autores principales: Chen, Miao, Long, Qian, Borrie, Melinda S., Sun, Haohui, Zhang, Changlin, Yang, Han, Shi, Dingbo, Gartenberg, Marc R., Deng, Wuguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639082/
https://www.ncbi.nlm.nih.gov/pubmed/34793452
http://dx.doi.org/10.1371/journal.pgen.1009899