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Nucleoporin TPR promotes tRNA nuclear export and protein synthesis in lung cancer cells
The robust proliferation of cancer cells requires vastly elevated levels of protein synthesis, which relies on a steady supply of aminoacylated tRNAs. Delivery of tRNAs to the cytoplasm is a highly regulated process, but the machinery for tRNA nuclear export is not fully elucidated. In this study, u...
Autores principales: | Chen, Miao, Long, Qian, Borrie, Melinda S., Sun, Haohui, Zhang, Changlin, Yang, Han, Shi, Dingbo, Gartenberg, Marc R., Deng, Wuguo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639082/ https://www.ncbi.nlm.nih.gov/pubmed/34793452 http://dx.doi.org/10.1371/journal.pgen.1009899 |
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